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Atypical frontoamygdala functional connectivity in youth with autism

Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-...

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Autores principales: Odriozola, Paola, Dajani, Dina R., Burrows, Catherine A., Gabard-Durnam, Laurel J., Goodman, Emma, Baez, Adriana C., Tottenham, Nim, Uddin, Lucina Q., Gee, Dylan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570504/
https://www.ncbi.nlm.nih.gov/pubmed/30581125
http://dx.doi.org/10.1016/j.dcn.2018.12.001
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author Odriozola, Paola
Dajani, Dina R.
Burrows, Catherine A.
Gabard-Durnam, Laurel J.
Goodman, Emma
Baez, Adriana C.
Tottenham, Nim
Uddin, Lucina Q.
Gee, Dylan G.
author_facet Odriozola, Paola
Dajani, Dina R.
Burrows, Catherine A.
Gabard-Durnam, Laurel J.
Goodman, Emma
Baez, Adriana C.
Tottenham, Nim
Uddin, Lucina Q.
Gee, Dylan G.
author_sort Odriozola, Paola
collection PubMed
description Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-related changes in frontoamygdala networks in ASD. Here we characterize frontoamygdala resting-state FC in a cross-sectional sample (ages 7–25) of 58 typically developing (TD) individuals and 53 individuals with ASD. Contrary to hypotheses, individuals with ASD did not show different age-related patterns of frontoamygdala FC compared with TD individuals. However, overall group differences in frontoamygdala FC were observed. Specifically, relative to TD individuals, individuals with ASD showed weaker frontoamygdala FC between the right basolateral (BL) amygdala and the rostral anterior cingulate cortex (rACC). These findings extend prior work to a broader developmental range in ASD, and indicate ASD-related differences in frontoamygdala FC that may underlie core socioemotional impairments in children and adolescents with ASD.
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spelling pubmed-65705042019-06-14 Atypical frontoamygdala functional connectivity in youth with autism Odriozola, Paola Dajani, Dina R. Burrows, Catherine A. Gabard-Durnam, Laurel J. Goodman, Emma Baez, Adriana C. Tottenham, Nim Uddin, Lucina Q. Gee, Dylan G. Dev Cogn Neurosci Original Research Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-related changes in frontoamygdala networks in ASD. Here we characterize frontoamygdala resting-state FC in a cross-sectional sample (ages 7–25) of 58 typically developing (TD) individuals and 53 individuals with ASD. Contrary to hypotheses, individuals with ASD did not show different age-related patterns of frontoamygdala FC compared with TD individuals. However, overall group differences in frontoamygdala FC were observed. Specifically, relative to TD individuals, individuals with ASD showed weaker frontoamygdala FC between the right basolateral (BL) amygdala and the rostral anterior cingulate cortex (rACC). These findings extend prior work to a broader developmental range in ASD, and indicate ASD-related differences in frontoamygdala FC that may underlie core socioemotional impairments in children and adolescents with ASD. Elsevier 2018-12-07 /pmc/articles/PMC6570504/ /pubmed/30581125 http://dx.doi.org/10.1016/j.dcn.2018.12.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Odriozola, Paola
Dajani, Dina R.
Burrows, Catherine A.
Gabard-Durnam, Laurel J.
Goodman, Emma
Baez, Adriana C.
Tottenham, Nim
Uddin, Lucina Q.
Gee, Dylan G.
Atypical frontoamygdala functional connectivity in youth with autism
title Atypical frontoamygdala functional connectivity in youth with autism
title_full Atypical frontoamygdala functional connectivity in youth with autism
title_fullStr Atypical frontoamygdala functional connectivity in youth with autism
title_full_unstemmed Atypical frontoamygdala functional connectivity in youth with autism
title_short Atypical frontoamygdala functional connectivity in youth with autism
title_sort atypical frontoamygdala functional connectivity in youth with autism
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570504/
https://www.ncbi.nlm.nih.gov/pubmed/30581125
http://dx.doi.org/10.1016/j.dcn.2018.12.001
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