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Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study

Skin and skin structure infection (SSSI) is classified as complicated (cSSSI) if it involves deep subcutaneous tissue or requires surgery. Factors associated with blood culture sampling and bacteremia have not been established in patients with cSSSI. Moreover, the benefit of information acquired fro...

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Autores principales: Halavaara, Mika, Jääskeläinen, Iiro H., Hagberg, Lars, Järvinen, Asko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570775/
https://www.ncbi.nlm.nih.gov/pubmed/31011854
http://dx.doi.org/10.1007/s10096-019-03560-9
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author Halavaara, Mika
Jääskeläinen, Iiro H.
Hagberg, Lars
Järvinen, Asko
author_facet Halavaara, Mika
Jääskeläinen, Iiro H.
Hagberg, Lars
Järvinen, Asko
author_sort Halavaara, Mika
collection PubMed
description Skin and skin structure infection (SSSI) is classified as complicated (cSSSI) if it involves deep subcutaneous tissue or requires surgery. Factors associated with blood culture sampling and bacteremia have not been established in patients with cSSSI. Moreover, the benefit of information acquired from positive blood culture is unknown. The aim of this study was to address these important issues. In this retrospective population-based study from two Nordic cities, a total of 460 patients with cSSSI were included. Blood cultures were drawn from 258 (56.1%) patients and they were positive in 61 (23.6%) of them. Factors found to be associated with more blood culture sampling in multivariate analysis were diabetes, duration of symptoms shorter than 2 days and higher C-reactive protein (CRP) level. Whereas factors associated with less frequent blood culture sampling were peripheral vascular disease and a surgical wound infection. In patients from whom blood cultures were taken, alcohol abuse was the only factor associated with culture positivity, as CRP level was not. Patients with a positive blood culture had antibiotic streamlining more often than non-bacteremic patients. A high rate of blood culture positivity in patients with cSSSI was observed. Factors related to more frequent blood culture sampling were different from those associated with a positive culture.
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spelling pubmed-65707752019-07-01 Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study Halavaara, Mika Jääskeläinen, Iiro H. Hagberg, Lars Järvinen, Asko Eur J Clin Microbiol Infect Dis Original Article Skin and skin structure infection (SSSI) is classified as complicated (cSSSI) if it involves deep subcutaneous tissue or requires surgery. Factors associated with blood culture sampling and bacteremia have not been established in patients with cSSSI. Moreover, the benefit of information acquired from positive blood culture is unknown. The aim of this study was to address these important issues. In this retrospective population-based study from two Nordic cities, a total of 460 patients with cSSSI were included. Blood cultures were drawn from 258 (56.1%) patients and they were positive in 61 (23.6%) of them. Factors found to be associated with more blood culture sampling in multivariate analysis were diabetes, duration of symptoms shorter than 2 days and higher C-reactive protein (CRP) level. Whereas factors associated with less frequent blood culture sampling were peripheral vascular disease and a surgical wound infection. In patients from whom blood cultures were taken, alcohol abuse was the only factor associated with culture positivity, as CRP level was not. Patients with a positive blood culture had antibiotic streamlining more often than non-bacteremic patients. A high rate of blood culture positivity in patients with cSSSI was observed. Factors related to more frequent blood culture sampling were different from those associated with a positive culture. Springer Berlin Heidelberg 2019-04-22 2019 /pmc/articles/PMC6570775/ /pubmed/31011854 http://dx.doi.org/10.1007/s10096-019-03560-9 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Halavaara, Mika
Jääskeläinen, Iiro H.
Hagberg, Lars
Järvinen, Asko
Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title_full Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title_fullStr Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title_full_unstemmed Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title_short Factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
title_sort factors associated with blood culture positivity in patients with complicated skin and skin structure infection—a population-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570775/
https://www.ncbi.nlm.nih.gov/pubmed/31011854
http://dx.doi.org/10.1007/s10096-019-03560-9
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