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Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

BACKGROUND: Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which is safely used in clinical practice to prevent nephrotoxicity of antibiotics. Tacrolimus (TAC) is the most important immunosuppressant in renal transplantation, but it causes considerable nephrotoxicity. We evaluated the protec...

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Detalles Bibliográficos
Autores principales:	Luo, Kang, Lim, Sun Woo, Jin, Jian, Jin, Long, Gil, Hyo Wook, Im, Dai Sig, Hwang, Hyeon Seok, Yang, Chul Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570925/ https://www.ncbi.nlm.nih.gov/pubmed/31200653 http://dx.doi.org/10.1186/s12882-019-1399-6

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