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Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions

PURPOSE OF REVIEW: Osteoarthritis (OA) is a subset of joint disorders resulting in degeneration of synovial joints. This leads to pain, disability and loss of independence. Knee and hip OA are extremely prevalent, and their occurrence increases with ageing. Similarly, loss of muscle mass and functio...

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Autores principales: Shorter, Emily, Sannicandro, Anthony J, Poulet, Blandine, Goljanek-Whysall, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571089/
https://www.ncbi.nlm.nih.gov/pubmed/31203463
http://dx.doi.org/10.1007/s11926-019-0839-4
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author Shorter, Emily
Sannicandro, Anthony J
Poulet, Blandine
Goljanek-Whysall, Katarzyna
author_facet Shorter, Emily
Sannicandro, Anthony J
Poulet, Blandine
Goljanek-Whysall, Katarzyna
author_sort Shorter, Emily
collection PubMed
description PURPOSE OF REVIEW: Osteoarthritis (OA) is a subset of joint disorders resulting in degeneration of synovial joints. This leads to pain, disability and loss of independence. Knee and hip OA are extremely prevalent, and their occurrence increases with ageing. Similarly, loss of muscle mass and function, sarcopenia, occurs during ageing. RECENT FINDINGS: Little is known about the impact of muscle wasting on OA progression; nevertheless, it has been suggested that muscle wasting directly affects the stability of the joints and loss of mobility leads to gradual degeneration of articular cartilage. The molecular mechanisms underlying muscle wasting in OA are not well understood; however, these are probably related to changes in gene expression, as well as epigenetic modifications. SUMMARY: It is becoming clear that skeletal muscle wasting plays an important role in OA development and/or progression. Here, we discuss mechanisms, current interventions, such as exercise, and potentially novel approaches, such as modulation of microRNAs, aiming at ameliorating OA symptoms through maintaining muscle mass and function.
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spelling pubmed-65710892019-07-02 Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions Shorter, Emily Sannicandro, Anthony J Poulet, Blandine Goljanek-Whysall, Katarzyna Curr Rheumatol Rep Osteoarthritis (M Goldring, Section Editor) PURPOSE OF REVIEW: Osteoarthritis (OA) is a subset of joint disorders resulting in degeneration of synovial joints. This leads to pain, disability and loss of independence. Knee and hip OA are extremely prevalent, and their occurrence increases with ageing. Similarly, loss of muscle mass and function, sarcopenia, occurs during ageing. RECENT FINDINGS: Little is known about the impact of muscle wasting on OA progression; nevertheless, it has been suggested that muscle wasting directly affects the stability of the joints and loss of mobility leads to gradual degeneration of articular cartilage. The molecular mechanisms underlying muscle wasting in OA are not well understood; however, these are probably related to changes in gene expression, as well as epigenetic modifications. SUMMARY: It is becoming clear that skeletal muscle wasting plays an important role in OA development and/or progression. Here, we discuss mechanisms, current interventions, such as exercise, and potentially novel approaches, such as modulation of microRNAs, aiming at ameliorating OA symptoms through maintaining muscle mass and function. Springer US 2019-06-15 2019 /pmc/articles/PMC6571089/ /pubmed/31203463 http://dx.doi.org/10.1007/s11926-019-0839-4 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Osteoarthritis (M Goldring, Section Editor)
Shorter, Emily
Sannicandro, Anthony J
Poulet, Blandine
Goljanek-Whysall, Katarzyna
Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title_full Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title_fullStr Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title_full_unstemmed Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title_short Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions
title_sort skeletal muscle wasting and its relationship with osteoarthritis: a mini-review of mechanisms and current interventions
topic Osteoarthritis (M Goldring, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571089/
https://www.ncbi.nlm.nih.gov/pubmed/31203463
http://dx.doi.org/10.1007/s11926-019-0839-4
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