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Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures

The aim of this study was to better understand the imaging features of drug-resistant epilepsy (DRE), especially in idiopathic generalized tonic-clonic seizure (GTCS), as well as to discover the associated mechanisms and functional connectivity (FC). A total of 31 idiopathic generalized epilepsy-GTC...

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Autores principales: Wang, Zhengge, Wang, Xiaoyun, Rong, Rong, Xu, Yun, Zhang, Bing, Wang, Zhongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571184/
https://www.ncbi.nlm.nih.gov/pubmed/31116131
http://dx.doi.org/10.1097/WNR.0000000000001262
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author Wang, Zhengge
Wang, Xiaoyun
Rong, Rong
Xu, Yun
Zhang, Bing
Wang, Zhongyuan
author_facet Wang, Zhengge
Wang, Xiaoyun
Rong, Rong
Xu, Yun
Zhang, Bing
Wang, Zhongyuan
author_sort Wang, Zhengge
collection PubMed
description The aim of this study was to better understand the imaging features of drug-resistant epilepsy (DRE), especially in idiopathic generalized tonic-clonic seizure (GTCS), as well as to discover the associated mechanisms and functional connectivity (FC). A total of 31 idiopathic generalized epilepsy-GTCS patients and 17 healthy controls were enrolled. For each patient, resting-state functional MRI was performed. After a 12-month follow-up observation, patients were further divided into either drug-resistant (DR) or drug-sensitive (DS) groups. Compared to the DS group, DR patients had previously received more types of antiepileptic drugs and had taken more types of failed antiepileptic drugs. There were distinct FC changes toward the left thalamus, left putamen, left precuneus, and right precentral gyrus in the left hippocampus between DR and DS patients. FCs in the DR group largely decreased or remained unchanged, while DS patients exhibited compensatory enhancement. Disease duration was negatively correlated with FC between the left hippocampus and the left thalamus–putamen in patients with DRE. Further, DRE patients had an extremely high area under the curve (0.978) and a cut-off FC between the left hippocampus and thalamus–putamen of 0.282. Together, hippocampal FCs in patients with DR GTCS were impaired and time-dependently correlated with disease duration. Hippocampal FCs in DS patients showed overall compensatory enhancement, which could be used as a sensitive and specific marker to identify and predict DR GTCS.
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spelling pubmed-65711842019-07-22 Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures Wang, Zhengge Wang, Xiaoyun Rong, Rong Xu, Yun Zhang, Bing Wang, Zhongyuan Neuroreport Clinical Neuroscience The aim of this study was to better understand the imaging features of drug-resistant epilepsy (DRE), especially in idiopathic generalized tonic-clonic seizure (GTCS), as well as to discover the associated mechanisms and functional connectivity (FC). A total of 31 idiopathic generalized epilepsy-GTCS patients and 17 healthy controls were enrolled. For each patient, resting-state functional MRI was performed. After a 12-month follow-up observation, patients were further divided into either drug-resistant (DR) or drug-sensitive (DS) groups. Compared to the DS group, DR patients had previously received more types of antiepileptic drugs and had taken more types of failed antiepileptic drugs. There were distinct FC changes toward the left thalamus, left putamen, left precuneus, and right precentral gyrus in the left hippocampus between DR and DS patients. FCs in the DR group largely decreased or remained unchanged, while DS patients exhibited compensatory enhancement. Disease duration was negatively correlated with FC between the left hippocampus and the left thalamus–putamen in patients with DRE. Further, DRE patients had an extremely high area under the curve (0.978) and a cut-off FC between the left hippocampus and thalamus–putamen of 0.282. Together, hippocampal FCs in patients with DR GTCS were impaired and time-dependently correlated with disease duration. Hippocampal FCs in DS patients showed overall compensatory enhancement, which could be used as a sensitive and specific marker to identify and predict DR GTCS. Lippincott Williams & Wilkins 2019-07-03 2019-05-08 /pmc/articles/PMC6571184/ /pubmed/31116131 http://dx.doi.org/10.1097/WNR.0000000000001262 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical Neuroscience
Wang, Zhengge
Wang, Xiaoyun
Rong, Rong
Xu, Yun
Zhang, Bing
Wang, Zhongyuan
Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title_full Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title_fullStr Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title_full_unstemmed Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title_short Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
title_sort impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures
topic Clinical Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571184/
https://www.ncbi.nlm.nih.gov/pubmed/31116131
http://dx.doi.org/10.1097/WNR.0000000000001262
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