Cargando…

Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study

This study compared the efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) vs primary surgical treatment (PST) in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB2/IIA2 cervical cancer. Data of 303 cervical cancer patients who re...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Hui, He, Yue, Zhu, Li-Rong, Wang, Jian-Liu, Guo, Hong-Yan, Xu, Ting, Wang, Yi-Qin, Yao, Ying, Wu, Yu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571268/
https://www.ncbi.nlm.nih.gov/pubmed/31124937
http://dx.doi.org/10.1097/MD.0000000000015604
_version_ 1783427376895492096
author Zhao, Hui
He, Yue
Zhu, Li-Rong
Wang, Jian-Liu
Guo, Hong-Yan
Xu, Ting
Wang, Yi-Qin
Yao, Ying
Wu, Yu-Mei
author_facet Zhao, Hui
He, Yue
Zhu, Li-Rong
Wang, Jian-Liu
Guo, Hong-Yan
Xu, Ting
Wang, Yi-Qin
Yao, Ying
Wu, Yu-Mei
author_sort Zhao, Hui
collection PubMed
description This study compared the efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) vs primary surgical treatment (PST) in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB2/IIA2 cervical cancer. Data of 303 cervical cancer patients who received primary therapy for stage IB2/IIA2 cervical cancer at 7 medical centers in Beijing, China between January 1, 2009 and December 31, 2016 and followed through December 31, 2017 were collected retrospectively. The response rates, surgical characteristics, and overall survival (OS) durations of patients who received NACT followed by RS were compared to those of patients who received PST. An improved short-term complete response rate was observed among patients who received intra-arterial chemotherapy compared with patients who had intravenous chemotherapy (18.3% vs 4.1%, P(difference) = .020). Patients who received NACT were more likely to undergo laparoscopic surgery and to have a lower blood loss volume (555.4 ± 520.2 ml vs PST, 682.5 ± 509.8 ml; P = .036) and increased estimated operative time (249.9 ± 101.9 vs PST, 225.1 ± 76.5 min; P = .022). No differences in high-risk factors (HRFs), the effects of supplemental treatment, or 5-year OS were observed between patients who received NACT and PST. Our findings indicate that patients who received NACT for FIGO stage IB2/IIA2 cervical cancer were more likely to undergo laparoscopic surgery. These findings have important implications regarding treatment with curative intent for stage IB2/IIA2 cervical cancer and warrant a further analysis of treatment strategies to ensure adequate treatment and patient-centered care.
format Online
Article
Text
id pubmed-6571268
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-65712682019-07-22 Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study Zhao, Hui He, Yue Zhu, Li-Rong Wang, Jian-Liu Guo, Hong-Yan Xu, Ting Wang, Yi-Qin Yao, Ying Wu, Yu-Mei Medicine (Baltimore) Research Article This study compared the efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) vs primary surgical treatment (PST) in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB2/IIA2 cervical cancer. Data of 303 cervical cancer patients who received primary therapy for stage IB2/IIA2 cervical cancer at 7 medical centers in Beijing, China between January 1, 2009 and December 31, 2016 and followed through December 31, 2017 were collected retrospectively. The response rates, surgical characteristics, and overall survival (OS) durations of patients who received NACT followed by RS were compared to those of patients who received PST. An improved short-term complete response rate was observed among patients who received intra-arterial chemotherapy compared with patients who had intravenous chemotherapy (18.3% vs 4.1%, P(difference) = .020). Patients who received NACT were more likely to undergo laparoscopic surgery and to have a lower blood loss volume (555.4 ± 520.2 ml vs PST, 682.5 ± 509.8 ml; P = .036) and increased estimated operative time (249.9 ± 101.9 vs PST, 225.1 ± 76.5 min; P = .022). No differences in high-risk factors (HRFs), the effects of supplemental treatment, or 5-year OS were observed between patients who received NACT and PST. Our findings indicate that patients who received NACT for FIGO stage IB2/IIA2 cervical cancer were more likely to undergo laparoscopic surgery. These findings have important implications regarding treatment with curative intent for stage IB2/IIA2 cervical cancer and warrant a further analysis of treatment strategies to ensure adequate treatment and patient-centered care. Wolters Kluwer Health 2019-05-24 /pmc/articles/PMC6571268/ /pubmed/31124937 http://dx.doi.org/10.1097/MD.0000000000015604 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Zhao, Hui
He, Yue
Zhu, Li-Rong
Wang, Jian-Liu
Guo, Hong-Yan
Xu, Ting
Wang, Yi-Qin
Yao, Ying
Wu, Yu-Mei
Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title_full Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title_fullStr Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title_full_unstemmed Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title_short Effect of neoadjuvant chemotherapy followed by radical surgery for FIGO stage IB2/IIA2 cervical cancer: A multi-center retrospective clinical study
title_sort effect of neoadjuvant chemotherapy followed by radical surgery for figo stage ib2/iia2 cervical cancer: a multi-center retrospective clinical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571268/
https://www.ncbi.nlm.nih.gov/pubmed/31124937
http://dx.doi.org/10.1097/MD.0000000000015604
work_keys_str_mv AT zhaohui effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT heyue effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT zhulirong effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT wangjianliu effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT guohongyan effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT xuting effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT wangyiqin effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT yaoying effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy
AT wuyumei effectofneoadjuvantchemotherapyfollowedbyradicalsurgeryforfigostageib2iia2cervicalcanceramulticenterretrospectiveclinicalstudy