Effects of wine on blood pressure, glucose parameters, and lipid profile in type 2 diabetes mellitus: A meta-analysis of randomized interventional trials (PRISMA Compliant)

BACKGROUND: Previous studies identified conflicting results about the effects of wine intake on glucose parameters and the risk of cardiovascular diseases in type 2 diabetes mellitus (T2DM). The present study further investigated the association between wine digestion and these outcomes in T2DM patients. MATERIAL AND METHODS: A search of PubMed, Embase, and Scopus databases (up to November 2018) was performed for randomized interventional trials which evaluated the effect of wine on blood pressure (BP), glucose parameters and lipid profiles in T2DM people. We used a variety of tests: fixed and random effects models, Q Cochrane test and I(2) index, Egger and Begg tests, forest plots, and sensitivity analysis in our study. RESULTS: A total of 9 randomized interventional studies were included in this meta-analysis. Overall, significant association between wine intake with diastolic BP (weighted mean difference [WMD] = 0.10; 95% confidence interval [95% CI]: −0.01 to 0.20, P = .03 I(2) = 13%) and total cholesterol (TC) (WMD = 0.16, 95% CI: 0.02–0.31, P = .03, I(2) = 6%), whereas no noticeable differences in glucose parameters, systolic BP, low-density lipoprotein cholesterol (LDLC), triglyceride (TG) and high-density lipoprotein cholesterol (HDLC) were identified between wine and controls groups (fasting glucose [FG],WMD = −0.00, 95% CI: −0.58 to 0.58; fasting insulin [FI], −0.22, −2.09 to 1.65; HbAc1%, −0.16, −0.40 to 0.07; systolic blood pressure, 0.12, −0.05 to 0.28; LDLC, −0.02, −0.25 to 0.21; TG, −0.34, −1.31 to 0.64; HDLC, 0.22, −0.08 to 0.53]. CONCLUSION: This meta-analysis revealed that moderate wine consumption among T2DM patients could reduce the level of diastolic blood pressure and TC, but not glucose parameters and other cardiovascular risk factors.