Cargando…

Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea

Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women wer...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Sae Kyung, Kim, Yeon Hee, Kim, Su Mi, Wie, Jung Ha, Lee, Dong-Gun, Kwon, Ji Young, Song, Jeong Hwa, Lee, Su Jeong, Park, In Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571384/
https://www.ncbi.nlm.nih.gov/pubmed/31124960
http://dx.doi.org/10.1097/MD.0000000000015756
_version_ 1783427403813486592
author Choi, Sae Kyung
Kim, Yeon Hee
Kim, Su Mi
Wie, Jung Ha
Lee, Dong-Gun
Kwon, Ji Young
Song, Jeong Hwa
Lee, Su Jeong
Park, In Yang
author_facet Choi, Sae Kyung
Kim, Yeon Hee
Kim, Su Mi
Wie, Jung Ha
Lee, Dong-Gun
Kwon, Ji Young
Song, Jeong Hwa
Lee, Su Jeong
Park, In Yang
author_sort Choi, Sae Kyung
collection PubMed
description Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012–December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups. A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT(3) serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups. Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care.
format Online
Article
Text
id pubmed-6571384
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-65713842019-07-22 Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea Choi, Sae Kyung Kim, Yeon Hee Kim, Su Mi Wie, Jung Ha Lee, Dong-Gun Kwon, Ji Young Song, Jeong Hwa Lee, Su Jeong Park, In Yang Medicine (Baltimore) Research Article Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012–December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups. A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT(3) serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups. Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care. Wolters Kluwer Health 2019-05-24 /pmc/articles/PMC6571384/ /pubmed/31124960 http://dx.doi.org/10.1097/MD.0000000000015756 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Choi, Sae Kyung
Kim, Yeon Hee
Kim, Su Mi
Wie, Jung Ha
Lee, Dong-Gun
Kwon, Ji Young
Song, Jeong Hwa
Lee, Su Jeong
Park, In Yang
Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title_full Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title_fullStr Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title_full_unstemmed Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title_short Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
title_sort opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in south korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571384/
https://www.ncbi.nlm.nih.gov/pubmed/31124960
http://dx.doi.org/10.1097/MD.0000000000015756
work_keys_str_mv AT choisaekyung opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT kimyeonhee opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT kimsumi opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT wiejungha opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT leedonggun opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT kwonjiyoung opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT songjeonghwa opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT leesujeong opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea
AT parkinyang opioidanalgesicsaretheleadingcauseofadversedrugreactionsintheobstetricpopulationinsouthkorea