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Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea
Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women wer...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571384/ https://www.ncbi.nlm.nih.gov/pubmed/31124960 http://dx.doi.org/10.1097/MD.0000000000015756 |
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author | Choi, Sae Kyung Kim, Yeon Hee Kim, Su Mi Wie, Jung Ha Lee, Dong-Gun Kwon, Ji Young Song, Jeong Hwa Lee, Su Jeong Park, In Yang |
author_facet | Choi, Sae Kyung Kim, Yeon Hee Kim, Su Mi Wie, Jung Ha Lee, Dong-Gun Kwon, Ji Young Song, Jeong Hwa Lee, Su Jeong Park, In Yang |
author_sort | Choi, Sae Kyung |
collection | PubMed |
description | Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012–December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups. A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT(3) serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups. Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care. |
format | Online Article Text |
id | pubmed-6571384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65713842019-07-22 Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea Choi, Sae Kyung Kim, Yeon Hee Kim, Su Mi Wie, Jung Ha Lee, Dong-Gun Kwon, Ji Young Song, Jeong Hwa Lee, Su Jeong Park, In Yang Medicine (Baltimore) Research Article Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown. We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications. Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012–December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups. A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT(3) serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups. Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care. Wolters Kluwer Health 2019-05-24 /pmc/articles/PMC6571384/ /pubmed/31124960 http://dx.doi.org/10.1097/MD.0000000000015756 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Choi, Sae Kyung Kim, Yeon Hee Kim, Su Mi Wie, Jung Ha Lee, Dong-Gun Kwon, Ji Young Song, Jeong Hwa Lee, Su Jeong Park, In Yang Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title | Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title_full | Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title_fullStr | Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title_full_unstemmed | Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title_short | Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea |
title_sort | opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in south korea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571384/ https://www.ncbi.nlm.nih.gov/pubmed/31124960 http://dx.doi.org/10.1097/MD.0000000000015756 |
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