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Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia
CXC chemokine receptor 4 (CXCR4) expression on acute myeloid leukemia (AML) cells correlated with stromal cell derived factor-1α (SDF-1α) and retained hematopoietic progenitors and leukemia cells within the bone marrow microenvironment. Here, we examined CXCR4 expression in 134 de novo AML and 21 co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571391/ https://www.ncbi.nlm.nih.gov/pubmed/31169718 http://dx.doi.org/10.1097/MD.0000000000015948 |
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author | Cao, Tingyong Ye, Yuanxin Liao, Hongyan Shuai, Xiao Jin, Yongmei Su, Jun Zheng, Qin |
author_facet | Cao, Tingyong Ye, Yuanxin Liao, Hongyan Shuai, Xiao Jin, Yongmei Su, Jun Zheng, Qin |
author_sort | Cao, Tingyong |
collection | PubMed |
description | CXC chemokine receptor 4 (CXCR4) expression on acute myeloid leukemia (AML) cells correlated with stromal cell derived factor-1α (SDF-1α) and retained hematopoietic progenitors and leukemia cells within the bone marrow microenvironment. Here, we examined CXCR4 expression in 134 de novo AML and 21 controls by flow cytometry, evaluated the relationship between CXCR4 expression and clinical characteristics, and elucidated the prognostic significance of CXCR4 expression in AML prospectively. We found that the CXCR4 expression was significantly higher in AML patients than controls (P = .000). One hundred thirty four cases of de novo AML patients were divided into 2 groups according to the median of CXCR4 relative fluorescence intensity (RFI). CXCR4 high group (RFI >4.23) had markedly shorter overall survival (OS) and disease-free survival (DFS) than CXCR4 low group (RFI ≤4.23) in 106 AML patients who received chemotherapy (P = .002; .026, respectively). Furthermore, in the 87 non-M3 patients who received induction therapy, there was a significant decrease for OS but not for DFS in the CXCR4 high group (P = .047 and .178, respectively). Moreover, high levels of CXCR4 expression independently increased the risk of relapse in both all AML and non-M3 patients who achieved complete remission (CR) after chemotherapy (odds ratio = 1.090, P = .010; odds ratio = 1.068, P = .048, respectively). Collectively, our data suggest that CXCR4 overexpression was an independent prognostic factor for disease relapse and poorer OS in both all AML and non-M3 patients. CXCR4 expression levels can be determined at disease presentation by the flow rapidly and easily. As such, CXCR4 could be used as a potential therapeutic target in AML patients with poor prognosis. |
format | Online Article Text |
id | pubmed-6571391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65713912019-07-22 Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia Cao, Tingyong Ye, Yuanxin Liao, Hongyan Shuai, Xiao Jin, Yongmei Su, Jun Zheng, Qin Medicine (Baltimore) Research Article CXC chemokine receptor 4 (CXCR4) expression on acute myeloid leukemia (AML) cells correlated with stromal cell derived factor-1α (SDF-1α) and retained hematopoietic progenitors and leukemia cells within the bone marrow microenvironment. Here, we examined CXCR4 expression in 134 de novo AML and 21 controls by flow cytometry, evaluated the relationship between CXCR4 expression and clinical characteristics, and elucidated the prognostic significance of CXCR4 expression in AML prospectively. We found that the CXCR4 expression was significantly higher in AML patients than controls (P = .000). One hundred thirty four cases of de novo AML patients were divided into 2 groups according to the median of CXCR4 relative fluorescence intensity (RFI). CXCR4 high group (RFI >4.23) had markedly shorter overall survival (OS) and disease-free survival (DFS) than CXCR4 low group (RFI ≤4.23) in 106 AML patients who received chemotherapy (P = .002; .026, respectively). Furthermore, in the 87 non-M3 patients who received induction therapy, there was a significant decrease for OS but not for DFS in the CXCR4 high group (P = .047 and .178, respectively). Moreover, high levels of CXCR4 expression independently increased the risk of relapse in both all AML and non-M3 patients who achieved complete remission (CR) after chemotherapy (odds ratio = 1.090, P = .010; odds ratio = 1.068, P = .048, respectively). Collectively, our data suggest that CXCR4 overexpression was an independent prognostic factor for disease relapse and poorer OS in both all AML and non-M3 patients. CXCR4 expression levels can be determined at disease presentation by the flow rapidly and easily. As such, CXCR4 could be used as a potential therapeutic target in AML patients with poor prognosis. Wolters Kluwer Health 2019-06-07 /pmc/articles/PMC6571391/ /pubmed/31169718 http://dx.doi.org/10.1097/MD.0000000000015948 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Cao, Tingyong Ye, Yuanxin Liao, Hongyan Shuai, Xiao Jin, Yongmei Su, Jun Zheng, Qin Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title | Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title_full | Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title_fullStr | Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title_full_unstemmed | Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title_short | Relationship between CXC chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
title_sort | relationship between cxc chemokine receptor 4 expression and prognostic significance in acute myeloid leukemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571391/ https://www.ncbi.nlm.nih.gov/pubmed/31169718 http://dx.doi.org/10.1097/MD.0000000000015948 |
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