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A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant

INTRODUCTION: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its orally active prodrug, capecitabine, are widely used in the treatment of gastrointestinal cancer, including colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) plays an important role in the 5-FU metabolism. Dihydropyrimidine...

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Detalles Bibliográficos
Autores principales:	De Falco, Vincenzo, Natalicchio, Maria Iole, Napolitano, Stefania, Coppola, Nicola, Conzo, Giovanni, Martinelli, Erika, Zanaletti, Nicoletta, Vitale, Pasquale, Giunta, Emilio Francesco, Vietri, Maria Teresa, Vitiello, Pietro Paolo, Ciardiello, Davide, Marinaccio, Anna, De Vita, Ferdinando, Ciardiello, Fortunato, Troiani, Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571425/ https://www.ncbi.nlm.nih.gov/pubmed/31124962 http://dx.doi.org/10.1097/MD.0000000000015759

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