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Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study
BACKGROUND: The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM: To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS: In a population-based cohort...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571483/ https://www.ncbi.nlm.nih.gov/pubmed/31231458 http://dx.doi.org/10.4239/wjd.v10.i6.350 |
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author | Haghighatdoost, Fahimeh Amini, Masoud Aminorroaya, Ashraf Abyar, Majid Feizi, Awat |
author_facet | Haghighatdoost, Fahimeh Amini, Masoud Aminorroaya, Ashraf Abyar, Majid Feizi, Awat |
author_sort | Haghighatdoost, Fahimeh |
collection | PubMed |
description | BACKGROUND: The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM: To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS: In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS: In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1; P < 0.05). CONCLUSION: Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated. |
format | Online Article Text |
id | pubmed-6571483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-65714832019-06-21 Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study Haghighatdoost, Fahimeh Amini, Masoud Aminorroaya, Ashraf Abyar, Majid Feizi, Awat World J Diabetes Observational Study BACKGROUND: The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM: To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS: In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS: In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1; P < 0.05). CONCLUSION: Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated. Baishideng Publishing Group Inc 2019-06-15 2019-06-15 /pmc/articles/PMC6571483/ /pubmed/31231458 http://dx.doi.org/10.4239/wjd.v10.i6.350 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Observational Study Haghighatdoost, Fahimeh Amini, Masoud Aminorroaya, Ashraf Abyar, Majid Feizi, Awat Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title_full | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title_fullStr | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title_full_unstemmed | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title_short | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study |
title_sort | different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: results from a 14-year cohort study |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571483/ https://www.ncbi.nlm.nih.gov/pubmed/31231458 http://dx.doi.org/10.4239/wjd.v10.i6.350 |
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