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Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined ass...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571589/ https://www.ncbi.nlm.nih.gov/pubmed/31035456 http://dx.doi.org/10.3390/jcm8050570 |
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author | Gagno, Giulia Padoan, Laura Stenner, Elisabetta Beleù, Alessandro Ziberna, Fabiana Hiche, Cristina Paldino, Alessia Barbati, Giulia Biolo, Gianni Fiotti, Nicola Not, Tarcisio Beltrami, Antonio Paolo Sinagra, Gianfranco Aleksova, Aneta |
author_facet | Gagno, Giulia Padoan, Laura Stenner, Elisabetta Beleù, Alessandro Ziberna, Fabiana Hiche, Cristina Paldino, Alessia Barbati, Giulia Biolo, Gianni Fiotti, Nicola Not, Tarcisio Beltrami, Antonio Paolo Sinagra, Gianfranco Aleksova, Aneta |
author_sort | Gagno, Giulia |
collection | PubMed |
description | Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event. Results: In total, 469 patients were included. The median Gal-3bp was 9.1 μg/mL (IQR 5.8–13.5 μg/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8–12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients’ age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78–0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality. Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI. |
format | Online Article Text |
id | pubmed-6571589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65715892019-06-18 Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction Gagno, Giulia Padoan, Laura Stenner, Elisabetta Beleù, Alessandro Ziberna, Fabiana Hiche, Cristina Paldino, Alessia Barbati, Giulia Biolo, Gianni Fiotti, Nicola Not, Tarcisio Beltrami, Antonio Paolo Sinagra, Gianfranco Aleksova, Aneta J Clin Med Article Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event. Results: In total, 469 patients were included. The median Gal-3bp was 9.1 μg/mL (IQR 5.8–13.5 μg/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8–12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients’ age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78–0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality. Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI. MDPI 2019-04-26 /pmc/articles/PMC6571589/ /pubmed/31035456 http://dx.doi.org/10.3390/jcm8050570 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gagno, Giulia Padoan, Laura Stenner, Elisabetta Beleù, Alessandro Ziberna, Fabiana Hiche, Cristina Paldino, Alessia Barbati, Giulia Biolo, Gianni Fiotti, Nicola Not, Tarcisio Beltrami, Antonio Paolo Sinagra, Gianfranco Aleksova, Aneta Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title | Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title_full | Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title_fullStr | Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title_full_unstemmed | Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title_short | Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction |
title_sort | galectin 3 and galectin 3 binding protein improve the risk stratification after myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571589/ https://www.ncbi.nlm.nih.gov/pubmed/31035456 http://dx.doi.org/10.3390/jcm8050570 |
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