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Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined ass...

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Autores principales: Gagno, Giulia, Padoan, Laura, Stenner, Elisabetta, Beleù, Alessandro, Ziberna, Fabiana, Hiche, Cristina, Paldino, Alessia, Barbati, Giulia, Biolo, Gianni, Fiotti, Nicola, Not, Tarcisio, Beltrami, Antonio Paolo, Sinagra, Gianfranco, Aleksova, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571589/
https://www.ncbi.nlm.nih.gov/pubmed/31035456
http://dx.doi.org/10.3390/jcm8050570
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author Gagno, Giulia
Padoan, Laura
Stenner, Elisabetta
Beleù, Alessandro
Ziberna, Fabiana
Hiche, Cristina
Paldino, Alessia
Barbati, Giulia
Biolo, Gianni
Fiotti, Nicola
Not, Tarcisio
Beltrami, Antonio Paolo
Sinagra, Gianfranco
Aleksova, Aneta
author_facet Gagno, Giulia
Padoan, Laura
Stenner, Elisabetta
Beleù, Alessandro
Ziberna, Fabiana
Hiche, Cristina
Paldino, Alessia
Barbati, Giulia
Biolo, Gianni
Fiotti, Nicola
Not, Tarcisio
Beltrami, Antonio Paolo
Sinagra, Gianfranco
Aleksova, Aneta
author_sort Gagno, Giulia
collection PubMed
description Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event. Results: In total, 469 patients were included. The median Gal-3bp was 9.1 μg/mL (IQR 5.8–13.5 μg/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8–12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients’ age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78–0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality. Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI.
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spelling pubmed-65715892019-06-18 Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction Gagno, Giulia Padoan, Laura Stenner, Elisabetta Beleù, Alessandro Ziberna, Fabiana Hiche, Cristina Paldino, Alessia Barbati, Giulia Biolo, Gianni Fiotti, Nicola Not, Tarcisio Beltrami, Antonio Paolo Sinagra, Gianfranco Aleksova, Aneta J Clin Med Article Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event. Results: In total, 469 patients were included. The median Gal-3bp was 9.1 μg/mL (IQR 5.8–13.5 μg/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8–12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients’ age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78–0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality. Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI. MDPI 2019-04-26 /pmc/articles/PMC6571589/ /pubmed/31035456 http://dx.doi.org/10.3390/jcm8050570 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gagno, Giulia
Padoan, Laura
Stenner, Elisabetta
Beleù, Alessandro
Ziberna, Fabiana
Hiche, Cristina
Paldino, Alessia
Barbati, Giulia
Biolo, Gianni
Fiotti, Nicola
Not, Tarcisio
Beltrami, Antonio Paolo
Sinagra, Gianfranco
Aleksova, Aneta
Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title_full Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title_fullStr Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title_full_unstemmed Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title_short Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction
title_sort galectin 3 and galectin 3 binding protein improve the risk stratification after myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571589/
https://www.ncbi.nlm.nih.gov/pubmed/31035456
http://dx.doi.org/10.3390/jcm8050570
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