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Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides

We have developed a robust solid-phase protocol which allowed the synthesis of chimeric oligonucleotides modified with phosphodiester and O-methylphosphonate linkages as well as their P-S and P-N variants. The novel O-methylphosphonate-derived modifications were obtained by oxidation, sulfurization,...

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Detalles Bibliográficos
Autores principales:	Kostov, Ondřej, Liboska, Radek, Páv, Ondřej, Novák, Pavel, Rosenberg, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571627/ https://www.ncbi.nlm.nih.gov/pubmed/31096640 http://dx.doi.org/10.3390/molecules24101872

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