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Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor

Testicular Sertoli cell tumors are extremely rare. Generally, they are benign neoplasms, which belong to a group called sex cord–stromal tumors. In this article, we present a case report of a Sertoli cell tumor, which was accidentally discovered during a urological consultation of a 42-year-old male...

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Autores principales: Anglickis, Marius, Stulpinas, Rokas, Anglickienė, Giedrė, Gabrilevičius, Justinas, Jaškevičius, Arūnas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571665/
https://www.ncbi.nlm.nih.gov/pubmed/31137577
http://dx.doi.org/10.3390/medicina55050170
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author Anglickis, Marius
Stulpinas, Rokas
Anglickienė, Giedrė
Gabrilevičius, Justinas
Jaškevičius, Arūnas
author_facet Anglickis, Marius
Stulpinas, Rokas
Anglickienė, Giedrė
Gabrilevičius, Justinas
Jaškevičius, Arūnas
author_sort Anglickis, Marius
collection PubMed
description Testicular Sertoli cell tumors are extremely rare. Generally, they are benign neoplasms, which belong to a group called sex cord–stromal tumors. In this article, we present a case report of a Sertoli cell tumor, which was accidentally discovered during a urological consultation of a 42-year-old male. An ultrasound showed a 2.1 × 2.2 cm hypoechogenic, hypervascular tumor in the middle third of the left testicle. Serum tumor markers (α-fetoprotein, alkaline phosphatase, β-human chorionic gonadotropin, and lactic dehydrogenase) were all within the normal range. Rapid microscopic evaluation of fresh frozen sections during the operation was inconclusive, which led to a decision not to perform a radical orchiectomy immediately. On formalin-fixed paraffin-embedded (FFPE) sections, the tumor histology showed atypical patterns, and immunohistochemical analysis was performed in order to determine the type of neoplasm and differentiate it from other types of testicular tumors, so as to assign the further course of treatment. Radical inguinal orchiectomy was performed. The final pathology report showed a tumor with no predictive signs of aggressive behavior, which most closely resembled a Sertoli cell tumor.
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spelling pubmed-65716652019-06-18 Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor Anglickis, Marius Stulpinas, Rokas Anglickienė, Giedrė Gabrilevičius, Justinas Jaškevičius, Arūnas Medicina (Kaunas) Case Report Testicular Sertoli cell tumors are extremely rare. Generally, they are benign neoplasms, which belong to a group called sex cord–stromal tumors. In this article, we present a case report of a Sertoli cell tumor, which was accidentally discovered during a urological consultation of a 42-year-old male. An ultrasound showed a 2.1 × 2.2 cm hypoechogenic, hypervascular tumor in the middle third of the left testicle. Serum tumor markers (α-fetoprotein, alkaline phosphatase, β-human chorionic gonadotropin, and lactic dehydrogenase) were all within the normal range. Rapid microscopic evaluation of fresh frozen sections during the operation was inconclusive, which led to a decision not to perform a radical orchiectomy immediately. On formalin-fixed paraffin-embedded (FFPE) sections, the tumor histology showed atypical patterns, and immunohistochemical analysis was performed in order to determine the type of neoplasm and differentiate it from other types of testicular tumors, so as to assign the further course of treatment. Radical inguinal orchiectomy was performed. The final pathology report showed a tumor with no predictive signs of aggressive behavior, which most closely resembled a Sertoli cell tumor. MDPI 2019-05-20 /pmc/articles/PMC6571665/ /pubmed/31137577 http://dx.doi.org/10.3390/medicina55050170 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Anglickis, Marius
Stulpinas, Rokas
Anglickienė, Giedrė
Gabrilevičius, Justinas
Jaškevičius, Arūnas
Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title_full Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title_fullStr Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title_full_unstemmed Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title_short Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor
title_sort case report of misleading features of a rare sertoli cell testicular tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571665/
https://www.ncbi.nlm.nih.gov/pubmed/31137577
http://dx.doi.org/10.3390/medicina55050170
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