Cargando…

Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects

The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabe...

Descripción completa

Detalles Bibliográficos
Autores principales: Castelblanco, Esmeralda, Sanjurjo, Lucía, Falguera, Mireia, Hernández, Marta, Fernandez-Real, José-Manuel, Sarrias, Maria-Rosa, Alonso, Nuria, Mauricio, Didac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571689/
https://www.ncbi.nlm.nih.gov/pubmed/31109109
http://dx.doi.org/10.3390/jcm8050710
_version_ 1783427467373969408
author Castelblanco, Esmeralda
Sanjurjo, Lucía
Falguera, Mireia
Hernández, Marta
Fernandez-Real, José-Manuel
Sarrias, Maria-Rosa
Alonso, Nuria
Mauricio, Didac
author_facet Castelblanco, Esmeralda
Sanjurjo, Lucía
Falguera, Mireia
Hernández, Marta
Fernandez-Real, José-Manuel
Sarrias, Maria-Rosa
Alonso, Nuria
Mauricio, Didac
author_sort Castelblanco, Esmeralda
collection PubMed
description The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (p = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0.180), non-diabetic versus T2D subjects (p = 0.583), and T1D versus T2D patients (p = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0.001), tobacco exposure (p = 0.006), T2D (p = 0.020), and a higher-platelets count (p = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D.
format Online
Article
Text
id pubmed-6571689
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65716892019-06-18 Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects Castelblanco, Esmeralda Sanjurjo, Lucía Falguera, Mireia Hernández, Marta Fernandez-Real, José-Manuel Sarrias, Maria-Rosa Alonso, Nuria Mauricio, Didac J Clin Med Article The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (p = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0.180), non-diabetic versus T2D subjects (p = 0.583), and T1D versus T2D patients (p = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0.001), tobacco exposure (p = 0.006), T2D (p = 0.020), and a higher-platelets count (p = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D. MDPI 2019-05-18 /pmc/articles/PMC6571689/ /pubmed/31109109 http://dx.doi.org/10.3390/jcm8050710 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castelblanco, Esmeralda
Sanjurjo, Lucía
Falguera, Mireia
Hernández, Marta
Fernandez-Real, José-Manuel
Sarrias, Maria-Rosa
Alonso, Nuria
Mauricio, Didac
Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title_full Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title_fullStr Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title_full_unstemmed Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title_short Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
title_sort circulating soluble cd36 is similar in type 1 and type 2 diabetes mellitus versus non-diabetic subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571689/
https://www.ncbi.nlm.nih.gov/pubmed/31109109
http://dx.doi.org/10.3390/jcm8050710
work_keys_str_mv AT castelblancoesmeralda circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT sanjurjolucia circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT falgueramireia circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT hernandezmarta circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT fernandezrealjosemanuel circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT sarriasmariarosa circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT alonsonuria circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects
AT mauriciodidac circulatingsolublecd36issimilarintype1andtype2diabetesmellitusversusnondiabeticsubjects