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Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties

Acute thrombosis remains the main limitation of small-diameter vascular grafts (inner diameter <6 mm) for bridging and bypassing of small arteries defects and occlusion. The use of hydrogel tubes represents a promising strategy. However, their low mechanical strength and high swelling tendency ma...

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Autores principales: Guan, Guoping, Yu, Chenglong, Xing, Meiyi, Wu, Yufen, Hu, Xingyou, Wang, Hongjun, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571729/
https://www.ncbi.nlm.nih.gov/pubmed/31064087
http://dx.doi.org/10.3390/polym11050810
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author Guan, Guoping
Yu, Chenglong
Xing, Meiyi
Wu, Yufen
Hu, Xingyou
Wang, Hongjun
Wang, Lu
author_facet Guan, Guoping
Yu, Chenglong
Xing, Meiyi
Wu, Yufen
Hu, Xingyou
Wang, Hongjun
Wang, Lu
author_sort Guan, Guoping
collection PubMed
description Acute thrombosis remains the main limitation of small-diameter vascular grafts (inner diameter <6 mm) for bridging and bypassing of small arteries defects and occlusion. The use of hydrogel tubes represents a promising strategy. However, their low mechanical strength and high swelling tendency may limit their further application. In the present study, a hydrogel vascular graft of Ca alginate/polyacrylamide reinforced with a braided fiber strut was designed and fabricated with the assistance of a customized casting mold. Morphology, structure, swellability, mechanical properties, cyto- and hemocompatibility of the reinforced graft were characterized. The results showed that the reinforced graft was transparent and robust, with a smooth surface. Scanning electron microscopic examination confirmed a uniform porous structure throughout the hydrogel. The swelling of the reinforced grafts could be controlled to 100%, obtaining clinically satisfactory mechanical properties. In particular, the dynamic circumferential compliance reached (1.7 ± 0.1)%/100 mmHg for 50–90 mmHg, a value significantly higher than that of expanded polytetrafluoroethylene (ePTFE) vascular grafts. Biological tests revealed that the reinforced graft was non-cytotoxic and had a low hemolysis percentage (HP) corresponding to (0.9 ± 0.2)%. In summary, the braided fiber-reinforced hydrogel vascular grafts demonstrated both physical and biological superiority, suggesting their suitability for vascular grafts.
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spelling pubmed-65717292019-06-18 Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties Guan, Guoping Yu, Chenglong Xing, Meiyi Wu, Yufen Hu, Xingyou Wang, Hongjun Wang, Lu Polymers (Basel) Article Acute thrombosis remains the main limitation of small-diameter vascular grafts (inner diameter <6 mm) for bridging and bypassing of small arteries defects and occlusion. The use of hydrogel tubes represents a promising strategy. However, their low mechanical strength and high swelling tendency may limit their further application. In the present study, a hydrogel vascular graft of Ca alginate/polyacrylamide reinforced with a braided fiber strut was designed and fabricated with the assistance of a customized casting mold. Morphology, structure, swellability, mechanical properties, cyto- and hemocompatibility of the reinforced graft were characterized. The results showed that the reinforced graft was transparent and robust, with a smooth surface. Scanning electron microscopic examination confirmed a uniform porous structure throughout the hydrogel. The swelling of the reinforced grafts could be controlled to 100%, obtaining clinically satisfactory mechanical properties. In particular, the dynamic circumferential compliance reached (1.7 ± 0.1)%/100 mmHg for 50–90 mmHg, a value significantly higher than that of expanded polytetrafluoroethylene (ePTFE) vascular grafts. Biological tests revealed that the reinforced graft was non-cytotoxic and had a low hemolysis percentage (HP) corresponding to (0.9 ± 0.2)%. In summary, the braided fiber-reinforced hydrogel vascular grafts demonstrated both physical and biological superiority, suggesting their suitability for vascular grafts. MDPI 2019-05-06 /pmc/articles/PMC6571729/ /pubmed/31064087 http://dx.doi.org/10.3390/polym11050810 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guan, Guoping
Yu, Chenglong
Xing, Meiyi
Wu, Yufen
Hu, Xingyou
Wang, Hongjun
Wang, Lu
Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title_full Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title_fullStr Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title_full_unstemmed Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title_short Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties
title_sort hydrogel small-diameter vascular graft reinforced with a braided fiber strut with improved mechanical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571729/
https://www.ncbi.nlm.nih.gov/pubmed/31064087
http://dx.doi.org/10.3390/polym11050810
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