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Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years
Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571736/ https://www.ncbi.nlm.nih.gov/pubmed/31027324 http://dx.doi.org/10.3390/jcm8050566 |
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author | Sentani, Kazuhiro Ogawa, Ikuko Ozasa, Kotaro Sadakane, Atsuko Utada, Mai Tsuya, Takafumi Kajihara, Hiroki Yonehara, Shuji Takeshima, Yukio Yasui, Wataru |
author_facet | Sentani, Kazuhiro Ogawa, Ikuko Ozasa, Kotaro Sadakane, Atsuko Utada, Mai Tsuya, Takafumi Kajihara, Hiroki Yonehara, Shuji Takeshima, Yukio Yasui, Wataru |
author_sort | Sentani, Kazuhiro |
collection | PubMed |
description | Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tumors and malignant tumors increased with age until 60–69 years and then declined. Among the 5015 salivary gland neoplasms, 3998 (80%) were benign and 1017 (20%) were malignant. Pleomorphic adenoma (PA) was the most frequent benign tumor (68%), followed by Warthin tumor (26%). Adenoid cystic carcinoma (ACC) (27%) and mucoepidermoid carcinoma (MEC) (26%) were the two most frequent malignant tumors. Characteristically, there was a very low incidence of polymorphous adenocarcinoma in Japan. The average annual age-adjusted incidence rate per 100,000 population was 3.3 for benign tumors and 0.8 for malignant tumors. This is the large-scale multi-institutional analysis to describe the characteristics of salivary gland neoplasms, based on the pathological tissue registry data. We hope that the present data can contribute to early diagnosis and effective treatment of salivary gland tumors and to cancer prevention. |
format | Online Article Text |
id | pubmed-6571736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65717362019-06-18 Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years Sentani, Kazuhiro Ogawa, Ikuko Ozasa, Kotaro Sadakane, Atsuko Utada, Mai Tsuya, Takafumi Kajihara, Hiroki Yonehara, Shuji Takeshima, Yukio Yasui, Wataru J Clin Med Article Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tumors and malignant tumors increased with age until 60–69 years and then declined. Among the 5015 salivary gland neoplasms, 3998 (80%) were benign and 1017 (20%) were malignant. Pleomorphic adenoma (PA) was the most frequent benign tumor (68%), followed by Warthin tumor (26%). Adenoid cystic carcinoma (ACC) (27%) and mucoepidermoid carcinoma (MEC) (26%) were the two most frequent malignant tumors. Characteristically, there was a very low incidence of polymorphous adenocarcinoma in Japan. The average annual age-adjusted incidence rate per 100,000 population was 3.3 for benign tumors and 0.8 for malignant tumors. This is the large-scale multi-institutional analysis to describe the characteristics of salivary gland neoplasms, based on the pathological tissue registry data. We hope that the present data can contribute to early diagnosis and effective treatment of salivary gland tumors and to cancer prevention. MDPI 2019-04-26 /pmc/articles/PMC6571736/ /pubmed/31027324 http://dx.doi.org/10.3390/jcm8050566 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sentani, Kazuhiro Ogawa, Ikuko Ozasa, Kotaro Sadakane, Atsuko Utada, Mai Tsuya, Takafumi Kajihara, Hiroki Yonehara, Shuji Takeshima, Yukio Yasui, Wataru Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title | Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title_full | Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title_fullStr | Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title_full_unstemmed | Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title_short | Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years |
title_sort | characteristics of 5015 salivary gland neoplasms registered in the hiroshima tumor tissue registry over a period of 39 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571736/ https://www.ncbi.nlm.nih.gov/pubmed/31027324 http://dx.doi.org/10.3390/jcm8050566 |
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