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Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism

The aim of the present study was to analyze possible relationships between pulmonary vessel obstruction and clinically relevant parameters and scores in patients with pulmonary embolism (PE). Overall, 246 patients (48.8% women and 51.2% men) with a mean age of 64.0 ± 17.1 years were involved in the...

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Autores principales: Lerche, Marianne, Bailis, Nikolaos, Akritidou, Mideia, Meyer, Hans Jonas, Surov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571763/
https://www.ncbi.nlm.nih.gov/pubmed/31035342
http://dx.doi.org/10.3390/jcm8050584
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author Lerche, Marianne
Bailis, Nikolaos
Akritidou, Mideia
Meyer, Hans Jonas
Surov, Alexey
author_facet Lerche, Marianne
Bailis, Nikolaos
Akritidou, Mideia
Meyer, Hans Jonas
Surov, Alexey
author_sort Lerche, Marianne
collection PubMed
description The aim of the present study was to analyze possible relationships between pulmonary vessel obstruction and clinically relevant parameters and scores in patients with pulmonary embolism (PE). Overall, 246 patients (48.8% women and 51.2% men) with a mean age of 64.0 ± 17.1 years were involved in the retrospective study. The following clinical scores were calculated in the patients: Wells score, Geneva score, and pulmonary embolism severity index (PESI) score. Levels of D-dimer (µg/mL), lactate, pH, troponin, and N-terminal natriuretic peptide (BNP, pg/mL) were acquired. Thrombotic obstruction of the pulmonary arteries was quantified according to Mastora score. The data collected were evaluated by means of descriptive statistics. Spearman’s correlation coefficient was used to analyze associations between the investigated parameters. P values < 0.05 were taken to indicate statistical significance. Mastora score correlated weakly with lactate level and tended to correlate with D-dimer and BNP levels. No other clinical or serological parameters correlated significantly with clot burden. Thrombotic obstruction of pulmonary vessels did not correlate with clinical severity of PE.
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spelling pubmed-65717632019-06-18 Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism Lerche, Marianne Bailis, Nikolaos Akritidou, Mideia Meyer, Hans Jonas Surov, Alexey J Clin Med Article The aim of the present study was to analyze possible relationships between pulmonary vessel obstruction and clinically relevant parameters and scores in patients with pulmonary embolism (PE). Overall, 246 patients (48.8% women and 51.2% men) with a mean age of 64.0 ± 17.1 years were involved in the retrospective study. The following clinical scores were calculated in the patients: Wells score, Geneva score, and pulmonary embolism severity index (PESI) score. Levels of D-dimer (µg/mL), lactate, pH, troponin, and N-terminal natriuretic peptide (BNP, pg/mL) were acquired. Thrombotic obstruction of the pulmonary arteries was quantified according to Mastora score. The data collected were evaluated by means of descriptive statistics. Spearman’s correlation coefficient was used to analyze associations between the investigated parameters. P values < 0.05 were taken to indicate statistical significance. Mastora score correlated weakly with lactate level and tended to correlate with D-dimer and BNP levels. No other clinical or serological parameters correlated significantly with clot burden. Thrombotic obstruction of pulmonary vessels did not correlate with clinical severity of PE. MDPI 2019-04-28 /pmc/articles/PMC6571763/ /pubmed/31035342 http://dx.doi.org/10.3390/jcm8050584 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lerche, Marianne
Bailis, Nikolaos
Akritidou, Mideia
Meyer, Hans Jonas
Surov, Alexey
Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title_full Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title_fullStr Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title_full_unstemmed Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title_short Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
title_sort pulmonary vessel obstruction does not correlate with severity of pulmonary embolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571763/
https://www.ncbi.nlm.nih.gov/pubmed/31035342
http://dx.doi.org/10.3390/jcm8050584
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