Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma membrane. However, the dynamics of nicotine entry into...

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Detalles Bibliográficos
Autores principales: Shivange, Amol V., Borden, Philip M., Muthusamy, Anand K., Nichols, Aaron L., Bera, Kallol, Bao, Huan, Bishara, Ishak, Jeon, Janice, Mulcahy, Matthew J., Cohen, Bruce, O'Riordan, Saidhbhe L., Kim, Charlene, Dougherty, Dennis A., Chapman, Edwin R., Marvin, Jonathan S., Looger, Loren L., Lester, Henry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571994/
https://www.ncbi.nlm.nih.gov/pubmed/30718376
http://dx.doi.org/10.1085/jgp.201812201

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