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Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic

2-hydroxyethyl methacrylate, methylmethacrylate, ethylene glycol dimethyl methacrylate, and lignocaine (drug) were mixed together and the monomers were copolymerized at 60 °C through a free radical polymerization in the presence of α,α′-Azoisobutyronitrile in tetrahydrofuran. A series of copolymer/d...

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Autores principales: Aouak, Taieb, Saeed, Wassem Sharaf, Al-Hafi, Nawaf M., Al-Odayni, Abdel-Basit, Alghamdi, Abdulaziz Ali, Bedja, Idriss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572039/
https://www.ncbi.nlm.nih.gov/pubmed/31126165
http://dx.doi.org/10.3390/polym11050917
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author Aouak, Taieb
Saeed, Wassem Sharaf
Al-Hafi, Nawaf M.
Al-Odayni, Abdel-Basit
Alghamdi, Abdulaziz Ali
Bedja, Idriss
author_facet Aouak, Taieb
Saeed, Wassem Sharaf
Al-Hafi, Nawaf M.
Al-Odayni, Abdel-Basit
Alghamdi, Abdulaziz Ali
Bedja, Idriss
author_sort Aouak, Taieb
collection PubMed
description 2-hydroxyethyl methacrylate, methylmethacrylate, ethylene glycol dimethyl methacrylate, and lignocaine (drug) were mixed together and the monomers were copolymerized at 60 °C through a free radical polymerization in the presence of α,α′-Azoisobutyronitrile in tetrahydrofuran. A series of copolymer/drug composites with different monoacrylate monomer compositions were prepared by solvent evaporation and characterized by different methods such as nuclear magnetic resonance, differential scanning calorimetry, Fourier transform infrared, X-ray diffraction, and mechanical and optical testing. The water content in the copolymers and the cell viability test on the samples were also examined in this investigation. The results of the analyses of the properties of this drug-carrier system are promising, indicating that this material may be a potential candidate for contact lens applications. The release dynamic of this medication from the prepared drug-carrier systems was investigated in neutral pH media. The results obtained revealed that the diffusion of lignocaine through the copolymer matrix obeys the Fick model and the dynamic release can be easily controlled by the methyl methacrylate content in the copolymer.
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spelling pubmed-65720392019-06-18 Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic Aouak, Taieb Saeed, Wassem Sharaf Al-Hafi, Nawaf M. Al-Odayni, Abdel-Basit Alghamdi, Abdulaziz Ali Bedja, Idriss Polymers (Basel) Article 2-hydroxyethyl methacrylate, methylmethacrylate, ethylene glycol dimethyl methacrylate, and lignocaine (drug) were mixed together and the monomers were copolymerized at 60 °C through a free radical polymerization in the presence of α,α′-Azoisobutyronitrile in tetrahydrofuran. A series of copolymer/drug composites with different monoacrylate monomer compositions were prepared by solvent evaporation and characterized by different methods such as nuclear magnetic resonance, differential scanning calorimetry, Fourier transform infrared, X-ray diffraction, and mechanical and optical testing. The water content in the copolymers and the cell viability test on the samples were also examined in this investigation. The results of the analyses of the properties of this drug-carrier system are promising, indicating that this material may be a potential candidate for contact lens applications. The release dynamic of this medication from the prepared drug-carrier systems was investigated in neutral pH media. The results obtained revealed that the diffusion of lignocaine through the copolymer matrix obeys the Fick model and the dynamic release can be easily controlled by the methyl methacrylate content in the copolymer. MDPI 2019-05-23 /pmc/articles/PMC6572039/ /pubmed/31126165 http://dx.doi.org/10.3390/polym11050917 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aouak, Taieb
Saeed, Wassem Sharaf
Al-Hafi, Nawaf M.
Al-Odayni, Abdel-Basit
Alghamdi, Abdulaziz Ali
Bedja, Idriss
Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title_full Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title_fullStr Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title_full_unstemmed Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title_short Poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic
title_sort poly (2-hydroxyethylmethacrylate –co–methylmethacrylate)/lignocaine contact lens preparation, characterization, and in vitro release dynamic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572039/
https://www.ncbi.nlm.nih.gov/pubmed/31126165
http://dx.doi.org/10.3390/polym11050917
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