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Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men

Black versus white older Americans are more likely to experience frailty, a condition associated with adverse health outcomes. To reduce racial disparities in health, a complete understanding of the pathophysiology of frailty is needed. Metabolomics may further our understanding by characterizing di...

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Autores principales: Marron, Megan M., Harris, Tamara B., Boudreau, Robert M., Clish, Clary B., Moore, Steven C., Murphy, Rachel A., Murthy, Venkatesh L., Sanders, Jason L., Shah, Ravi V., Tseng, George C., Wendell, Stacy G., Zmuda, Joseph M., Newman, Anne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572139/
https://www.ncbi.nlm.nih.gov/pubmed/31052232
http://dx.doi.org/10.3390/metabo9050083
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author Marron, Megan M.
Harris, Tamara B.
Boudreau, Robert M.
Clish, Clary B.
Moore, Steven C.
Murphy, Rachel A.
Murthy, Venkatesh L.
Sanders, Jason L.
Shah, Ravi V.
Tseng, George C.
Wendell, Stacy G.
Zmuda, Joseph M.
Newman, Anne B.
author_facet Marron, Megan M.
Harris, Tamara B.
Boudreau, Robert M.
Clish, Clary B.
Moore, Steven C.
Murphy, Rachel A.
Murthy, Venkatesh L.
Sanders, Jason L.
Shah, Ravi V.
Tseng, George C.
Wendell, Stacy G.
Zmuda, Joseph M.
Newman, Anne B.
author_sort Marron, Megan M.
collection PubMed
description Black versus white older Americans are more likely to experience frailty, a condition associated with adverse health outcomes. To reduce racial disparities in health, a complete understanding of the pathophysiology of frailty is needed. Metabolomics may further our understanding by characterizing differences in the body during a vigorous versus frail state. We sought to identify metabolites and biological pathways associated with vigor to frailty among 287 black men ages 70–81 from the Health, Aging, and Body Composition study. Using liquid chromatography-mass spectrometry, 350 metabolites were measured in overnight-fasting plasma. The Scale of Aging Vigor in Epidemiology (SAVE) measured vigor to frailty based on weight change, strength, energy, gait speed, and physical activity. Thirty-seven metabolites correlated with SAVE scores (p < 0.05), while adjusting for age and site. Fourteen metabolites remained significant after multiple comparisons adjustment (false discovery rate < 0.30). Lower values of tryptophan, methionine, tyrosine, asparagine, C14:0 sphingomyelin, and 1-methylnicotinamide, and higher values of glucoronate, N-carbamoyl-beta-alanine, isocitrate, creatinine, C4-OH carnitine, cystathionine, hydroxyphenylacetate, and putrescine were associated with frailer SAVE scores. Pathway analyses identified nitrogen metabolism, aminoacyl-tRNA biosynthesis, and the citric acid cycle. Future studies need to confirm these SAVE-associated metabolites and pathways that may indicate novel mechanisms involved in the frailty syndrome.
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spelling pubmed-65721392019-06-18 Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men Marron, Megan M. Harris, Tamara B. Boudreau, Robert M. Clish, Clary B. Moore, Steven C. Murphy, Rachel A. Murthy, Venkatesh L. Sanders, Jason L. Shah, Ravi V. Tseng, George C. Wendell, Stacy G. Zmuda, Joseph M. Newman, Anne B. Metabolites Article Black versus white older Americans are more likely to experience frailty, a condition associated with adverse health outcomes. To reduce racial disparities in health, a complete understanding of the pathophysiology of frailty is needed. Metabolomics may further our understanding by characterizing differences in the body during a vigorous versus frail state. We sought to identify metabolites and biological pathways associated with vigor to frailty among 287 black men ages 70–81 from the Health, Aging, and Body Composition study. Using liquid chromatography-mass spectrometry, 350 metabolites were measured in overnight-fasting plasma. The Scale of Aging Vigor in Epidemiology (SAVE) measured vigor to frailty based on weight change, strength, energy, gait speed, and physical activity. Thirty-seven metabolites correlated with SAVE scores (p < 0.05), while adjusting for age and site. Fourteen metabolites remained significant after multiple comparisons adjustment (false discovery rate < 0.30). Lower values of tryptophan, methionine, tyrosine, asparagine, C14:0 sphingomyelin, and 1-methylnicotinamide, and higher values of glucoronate, N-carbamoyl-beta-alanine, isocitrate, creatinine, C4-OH carnitine, cystathionine, hydroxyphenylacetate, and putrescine were associated with frailer SAVE scores. Pathway analyses identified nitrogen metabolism, aminoacyl-tRNA biosynthesis, and the citric acid cycle. Future studies need to confirm these SAVE-associated metabolites and pathways that may indicate novel mechanisms involved in the frailty syndrome. MDPI 2019-04-30 /pmc/articles/PMC6572139/ /pubmed/31052232 http://dx.doi.org/10.3390/metabo9050083 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marron, Megan M.
Harris, Tamara B.
Boudreau, Robert M.
Clish, Clary B.
Moore, Steven C.
Murphy, Rachel A.
Murthy, Venkatesh L.
Sanders, Jason L.
Shah, Ravi V.
Tseng, George C.
Wendell, Stacy G.
Zmuda, Joseph M.
Newman, Anne B.
Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title_full Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title_fullStr Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title_full_unstemmed Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title_short Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
title_sort metabolites associated with vigor to frailty among community-dwelling older black men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572139/
https://www.ncbi.nlm.nih.gov/pubmed/31052232
http://dx.doi.org/10.3390/metabo9050083
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