Cargando…

Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma

Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment....

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Chih-Jan, Li, Chia-Jung, Wu, Meng-Yu, Chu, Pei-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572154/
https://www.ncbi.nlm.nih.gov/pubmed/31126119
http://dx.doi.org/10.3390/ijerph16101836
_version_ 1783427574021488640
author Ko, Chih-Jan
Li, Chia-Jung
Wu, Meng-Yu
Chu, Pei-Yi
author_facet Ko, Chih-Jan
Li, Chia-Jung
Wu, Meng-Yu
Chu, Pei-Yi
author_sort Ko, Chih-Jan
collection PubMed
description Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment. The leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR-5) is a novel biomarker, particularly in stem cells, and is involved in embryogenesis, tumor development, and tumor cell signal transduction. Here, we investigated LGR-5 expression using immunohistochemistry and analyzed the correlation between clinical features and prognosis in patients with hepatocellular carcinoma (HCC). We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups. Thus, the LGR-5 marker is suggested to be a routine biomarker for poor prognosis, thereby providing a platform for anti-LGR-5-targeted therapy in the future.
format Online
Article
Text
id pubmed-6572154
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65721542019-06-18 Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma Ko, Chih-Jan Li, Chia-Jung Wu, Meng-Yu Chu, Pei-Yi Int J Environ Res Public Health Article Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment. The leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR-5) is a novel biomarker, particularly in stem cells, and is involved in embryogenesis, tumor development, and tumor cell signal transduction. Here, we investigated LGR-5 expression using immunohistochemistry and analyzed the correlation between clinical features and prognosis in patients with hepatocellular carcinoma (HCC). We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups. Thus, the LGR-5 marker is suggested to be a routine biomarker for poor prognosis, thereby providing a platform for anti-LGR-5-targeted therapy in the future. MDPI 2019-05-23 2019-05 /pmc/articles/PMC6572154/ /pubmed/31126119 http://dx.doi.org/10.3390/ijerph16101836 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Chih-Jan
Li, Chia-Jung
Wu, Meng-Yu
Chu, Pei-Yi
Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title_full Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title_fullStr Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title_full_unstemmed Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title_short Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
title_sort overexpression of lgr-5 as a predictor of poor outcome in patients with hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572154/
https://www.ncbi.nlm.nih.gov/pubmed/31126119
http://dx.doi.org/10.3390/ijerph16101836
work_keys_str_mv AT kochihjan overexpressionoflgr5asapredictorofpooroutcomeinpatientswithhepatocellularcarcinoma
AT lichiajung overexpressionoflgr5asapredictorofpooroutcomeinpatientswithhepatocellularcarcinoma
AT wumengyu overexpressionoflgr5asapredictorofpooroutcomeinpatientswithhepatocellularcarcinoma
AT chupeiyi overexpressionoflgr5asapredictorofpooroutcomeinpatientswithhepatocellularcarcinoma