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Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572154/ https://www.ncbi.nlm.nih.gov/pubmed/31126119 http://dx.doi.org/10.3390/ijerph16101836 |
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author | Ko, Chih-Jan Li, Chia-Jung Wu, Meng-Yu Chu, Pei-Yi |
author_facet | Ko, Chih-Jan Li, Chia-Jung Wu, Meng-Yu Chu, Pei-Yi |
author_sort | Ko, Chih-Jan |
collection | PubMed |
description | Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment. The leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR-5) is a novel biomarker, particularly in stem cells, and is involved in embryogenesis, tumor development, and tumor cell signal transduction. Here, we investigated LGR-5 expression using immunohistochemistry and analyzed the correlation between clinical features and prognosis in patients with hepatocellular carcinoma (HCC). We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups. Thus, the LGR-5 marker is suggested to be a routine biomarker for poor prognosis, thereby providing a platform for anti-LGR-5-targeted therapy in the future. |
format | Online Article Text |
id | pubmed-6572154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65721542019-06-18 Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma Ko, Chih-Jan Li, Chia-Jung Wu, Meng-Yu Chu, Pei-Yi Int J Environ Res Public Health Article Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment. The leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR-5) is a novel biomarker, particularly in stem cells, and is involved in embryogenesis, tumor development, and tumor cell signal transduction. Here, we investigated LGR-5 expression using immunohistochemistry and analyzed the correlation between clinical features and prognosis in patients with hepatocellular carcinoma (HCC). We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups. Thus, the LGR-5 marker is suggested to be a routine biomarker for poor prognosis, thereby providing a platform for anti-LGR-5-targeted therapy in the future. MDPI 2019-05-23 2019-05 /pmc/articles/PMC6572154/ /pubmed/31126119 http://dx.doi.org/10.3390/ijerph16101836 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Chih-Jan Li, Chia-Jung Wu, Meng-Yu Chu, Pei-Yi Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title | Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title_full | Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title_fullStr | Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title_full_unstemmed | Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title_short | Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma |
title_sort | overexpression of lgr-5 as a predictor of poor outcome in patients with hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572154/ https://www.ncbi.nlm.nih.gov/pubmed/31126119 http://dx.doi.org/10.3390/ijerph16101836 |
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