Cargando…

Norcantharidin Suppresses YD-15 Cell Invasion Through Inhibition of FAK/Paxillin and F-Actin Reorganization

Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported to exhibit activity against various types of cancers. However, the anti-invasive effects of NCTD and its molecular mechanism in human mucoepidermoid carcinoma (MEC) remain incompletely elucidated. Clonogenic, wound he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Kyoung-Ok, Ahn, Chi-Hyun, Yang, In-Hyoung, Han, Jung-Min, Shin, Ji-Ae, Cho, Sung-Dae, Hong, Seong Doo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572169/ https://www.ncbi.nlm.nih.gov/pubmed/31109130 http://dx.doi.org/10.3390/molecules24101928

Ejemplares similares

Contribution of p38 MAPK Pathway to Norcantharidin-Induced Programmed Cell Death in Human Oral Squamous Cell Carcinoma
por: Ahn, Chi-Hyun, et al.
Publicado: (2019)

Multiple paxillin binding sites regulate FAK function
por: Scheswohl, Danielle M, et al.
Publicado: (2008)

FAK and paxillin, two potential targets in pancreatic cancer
por: Kanteti, Rajani, et al.
Publicado: (2016)

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells
por: Hu, Ying-Li, et al.
Publicado: (2014)

Direct association of pp125FAK with paxillin, the focal adhesion- targeting mechanism of pp125FAK
Publicado: (1995)

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
por: Schaller, Michael D.
Publicado: (2004)

Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin
por: Shan, Yongli, et al.
Publicado: (2009)

Altering FAK-Paxillin Interactions Reduces Adhesion, Migration and Invasion Processes
por: Deramaudt, Thérèse B., et al.
Publicado: (2014)

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility
por: Subauste, M. Cecilia, et al.
Publicado: (2004)

Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart
por: Hirth, Sofia, et al.
Publicado: (2016)

Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway
por: Liao, Dan, et al.
Publicado: (2023)

Lidocaine inhibits the metastatic potential of ovarian cancer by blocking Na(V)1.5‐mediated EMT and FAK/Paxillin signaling pathway
por: Liu, Chang, et al.
Publicado: (2020)

F-actin cytoskeleton reorganization is associated with hepatic stellate cell activation
por: CUI, XIAODONG, et al.
Publicado: (2014)

CD151 mediates netrin‐1‐induced angiogenesis through the Src‐FAK‐Paxillin pathway
por: Yang, Xiaosheng, et al.
Publicado: (2016)

Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation
por: Kafi, Md Abdul, et al.
Publicado: (2020)

Understanding the Electronic Structures and Absorption Properties of Porphyrin Sensitizers YD2 and YD2-o-C8 for Dye-Sensitized Solar Cells
por: Han, Li-Heng, et al.
Publicado: (2013)

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion
por: Sachdev, Sanjay, et al.
Publicado: (2009)

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
por: Pasapera, Ana M., et al.
Publicado: (2010)

Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
por: Du, Tao, et al.
Publicado: (2014)

Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
por: Mousson, Antoine, et al.
Publicado: (2021)

F-actin reorganization by V-ATPase inhibition in prostate cancer
por: Licon-Munoz, Yamhilette, et al.
Publicado: (2017)

Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells
por: Son, Hwa-Kyung, et al.
Publicado: (2023)

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation
por: Ross, Sarah H., et al.
Publicado: (2012)

Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways
por: Cui, Shuna, et al.
Publicado: (2017)

Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton
por: Cui, Shuna, et al.
Publicado: (2018)

Bovine Lactoferricin Induces Intestinal Epithelial Cell Activation through Phosphorylation of FAK and Paxillin and Prevents Rotavirus Infection
por: Jeong, Ye Young, et al.
Publicado: (2021)

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation
por: Lu, Shiqi, et al.
Publicado: (2023)

Dynamic reorganization of the actin cytoskeleton
por: Letort, Gaëlle, et al.
Publicado: (2015)

Biodegradation of Inosine and Guanosine by Bacillus paranthracis YD01
por: Du, Xinyue, et al.
Publicado: (2023)

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
Publicado: (1992)

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma
por: Guo, Piao, et al.
Publicado: (2019)

Knockdown of interferon-stimulated gene 15 affects the sensitivity of hepatocellular carcinoma cells to norcantharidin
por: Chen, Baoxiang, et al.
Publicado: (2019)

A new insight into the apoptotic effect of nitidine chloride targeting Checkpoint kinase 2 in human cervical cancer in vitro
por: Kwon, Hye-Jeong, et al.
Publicado: (2019)

LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain
por: Smith, Mark A., et al.
Publicado: (2013)

TRPV2 interacts with actin and reorganizes submembranous actin cytoskeleton
por: Yadav, Manoj, et al.
Publicado: (2020)

Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex
por: Sakamoto, Ryota, et al.
Publicado: (2023)

Inhibition of Tumor Vasculogenic Mimicry and Prolongation of Host Survival in Highly Aggressive Gallbladder Cancers by Norcantharidin via Blocking the Ephrin Type a Receptor 2/Focal Adhesion Kinase/Paxillin Signaling Pathway
por: Wang, Hui, et al.
Publicado: (2014)

Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma
por: Sunrat, Chotchanit, et al.
Publicado: (2022)

Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
por: Hijazi, Nour, et al.
Publicado: (2023)

Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells
por: Kim, Yu Gyung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b6h7et3u4hfk0g90dn276o83j7