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Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment
Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by gastrointestinal and extraintestinal manifestations triggered after gluten ingestion in the absence of celiac disease and wheat allergy. Because of the lack of biomarkers for NCGS diagnosis, the cornerstone for its assessment is a s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572297/ https://www.ncbi.nlm.nih.gov/pubmed/31035487 http://dx.doi.org/10.3390/medicina55050117 |
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author | Figueroa-Salcido, Oscar Gerardo Ontiveros, Noé Cabrera-Chavez, Francisco |
author_facet | Figueroa-Salcido, Oscar Gerardo Ontiveros, Noé Cabrera-Chavez, Francisco |
author_sort | Figueroa-Salcido, Oscar Gerardo |
collection | PubMed |
description | Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by gastrointestinal and extraintestinal manifestations triggered after gluten ingestion in the absence of celiac disease and wheat allergy. Because of the lack of biomarkers for NCGS diagnosis, the cornerstone for its assessment is a single- or double-blind placebo-controlled (DBPC) gluten challenge. However, there are some non-standardized points in the diagnostic approach proposed by the experts. This complicate comparisons among the results published by different research groups. The gluten vehicle and placebo must be indistinguishable from each other, which entails sensory and technological evaluations of the designed gluten vehicle and placebo products. At the moment, there is no standardized method for the preparation of the gluten vehicle and placebo for carrying out DBPC gluten challenges for NCGS assessment. This review focuses on the challenges that researchers have to face, either for the development of an accepted gluten vehicle and placebo or for identifying NCGS cases on the basis of DBPC gluten challenges. |
format | Online Article Text |
id | pubmed-6572297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65722972019-06-18 Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment Figueroa-Salcido, Oscar Gerardo Ontiveros, Noé Cabrera-Chavez, Francisco Medicina (Kaunas) Review Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by gastrointestinal and extraintestinal manifestations triggered after gluten ingestion in the absence of celiac disease and wheat allergy. Because of the lack of biomarkers for NCGS diagnosis, the cornerstone for its assessment is a single- or double-blind placebo-controlled (DBPC) gluten challenge. However, there are some non-standardized points in the diagnostic approach proposed by the experts. This complicate comparisons among the results published by different research groups. The gluten vehicle and placebo must be indistinguishable from each other, which entails sensory and technological evaluations of the designed gluten vehicle and placebo products. At the moment, there is no standardized method for the preparation of the gluten vehicle and placebo for carrying out DBPC gluten challenges for NCGS assessment. This review focuses on the challenges that researchers have to face, either for the development of an accepted gluten vehicle and placebo or for identifying NCGS cases on the basis of DBPC gluten challenges. MDPI 2019-04-26 /pmc/articles/PMC6572297/ /pubmed/31035487 http://dx.doi.org/10.3390/medicina55050117 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Figueroa-Salcido, Oscar Gerardo Ontiveros, Noé Cabrera-Chavez, Francisco Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title | Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title_full | Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title_fullStr | Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title_full_unstemmed | Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title_short | Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment |
title_sort | gluten vehicle and placebo for non-celiac gluten sensitivity assessment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572297/ https://www.ncbi.nlm.nih.gov/pubmed/31035487 http://dx.doi.org/10.3390/medicina55050117 |
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