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Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid

Chitosan-based nanoparticles are promising materials for potential biomedical applications. We used Flash NanoPrecipitation as a rapid, scalable, single-step method to achieve self-assembly of crosslinked chitosan nanoparticles. Self-assembly was driven by electrostatic interactions, hydrogen bondin...

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Detalles Bibliográficos
Autores principales: Smith, Raven A., Walker, Rebecca C., Levit, Shani L., Tang, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572363/
https://www.ncbi.nlm.nih.gov/pubmed/31035564
http://dx.doi.org/10.3390/polym11050749
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author Smith, Raven A.
Walker, Rebecca C.
Levit, Shani L.
Tang, Christina
author_facet Smith, Raven A.
Walker, Rebecca C.
Levit, Shani L.
Tang, Christina
author_sort Smith, Raven A.
collection PubMed
description Chitosan-based nanoparticles are promising materials for potential biomedical applications. We used Flash NanoPrecipitation as a rapid, scalable, single-step method to achieve self-assembly of crosslinked chitosan nanoparticles. Self-assembly was driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions; tannic acid served to precipitate chitosan to seed nanoparticle formation and crosslink the chitosan to stabilize the resulting particles. The size of the nanoparticles can be tuned by varying formulation parameters including the total solids concentration and block copolymer to core mass ratio. We demonstrated that hydrophobic moieties can be incorporated into the nanoparticle using a lipophilic fluorescent dye as a model system.
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spelling pubmed-65723632019-06-18 Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid Smith, Raven A. Walker, Rebecca C. Levit, Shani L. Tang, Christina Polymers (Basel) Article Chitosan-based nanoparticles are promising materials for potential biomedical applications. We used Flash NanoPrecipitation as a rapid, scalable, single-step method to achieve self-assembly of crosslinked chitosan nanoparticles. Self-assembly was driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions; tannic acid served to precipitate chitosan to seed nanoparticle formation and crosslink the chitosan to stabilize the resulting particles. The size of the nanoparticles can be tuned by varying formulation parameters including the total solids concentration and block copolymer to core mass ratio. We demonstrated that hydrophobic moieties can be incorporated into the nanoparticle using a lipophilic fluorescent dye as a model system. MDPI 2019-04-27 /pmc/articles/PMC6572363/ /pubmed/31035564 http://dx.doi.org/10.3390/polym11050749 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smith, Raven A.
Walker, Rebecca C.
Levit, Shani L.
Tang, Christina
Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title_full Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title_fullStr Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title_full_unstemmed Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title_short Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid
title_sort single-step self-assembly and physical crosslinking of pegylated chitosan nanoparticles by tannic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572363/
https://www.ncbi.nlm.nih.gov/pubmed/31035564
http://dx.doi.org/10.3390/polym11050749
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