Cargando…
Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma
Despite the growing use of minimal clinically important difference (MCID) as a cancer outcome measure, no study has reported clinically significant outcomes in cancer patients. We defined MCID and evaluated the use of preoperative HRQoL for predicting MCID and survival after surgical resection of he...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572462/ https://www.ncbi.nlm.nih.gov/pubmed/31035539 http://dx.doi.org/10.3390/jcm8050576 |
_version_ | 1783427646181343232 |
---|---|
author | Chiu, Chong-Chi Lee, King-Teh Wang, Jhi-Joung Sun, Ding-Ping Lee, Hao-Hsien Huang, Chien-Cheng Shi, Hon-Yi |
author_facet | Chiu, Chong-Chi Lee, King-Teh Wang, Jhi-Joung Sun, Ding-Ping Lee, Hao-Hsien Huang, Chien-Cheng Shi, Hon-Yi |
author_sort | Chiu, Chong-Chi |
collection | PubMed |
description | Despite the growing use of minimal clinically important difference (MCID) as a cancer outcome measure, no study has reported clinically significant outcomes in cancer patients. We defined MCID and evaluated the use of preoperative HRQoL for predicting MCID and survival after surgical resection of hepatocellular carcinoma (HCC). In total, 369 patients completed the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and the SF-36 at baseline and at two years post-operative at three tertiary academic hospitals. The corresponding MCID values were 3.6 (SF-36 physical component summary), 4.2 (SF-36 mental component summary), 5.4 (FACT-General total score), and 6.7 (FACT-Hep total score). The predictors of achieving postoperative MCID were significantly higher in patients who had low preoperative HRQoL score, advanced age, high education level, and high BMI (p < 0.05). However, patients with a high preoperative HRQoL score, high education level, high BMI, and low Charlson comorbidity index score were significantly associated with survival (p < 0.05). Preoperative HRQoL scores were predictive of MCID and overall survival after surgical resection of HCC. The findings of this study may be useful for managing the preoperative expectations of candidates for HCC resection and for developing shared decision-making procedures for patients undergoing surgical resection of HCC. |
format | Online Article Text |
id | pubmed-6572462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65724622019-06-18 Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma Chiu, Chong-Chi Lee, King-Teh Wang, Jhi-Joung Sun, Ding-Ping Lee, Hao-Hsien Huang, Chien-Cheng Shi, Hon-Yi J Clin Med Article Despite the growing use of minimal clinically important difference (MCID) as a cancer outcome measure, no study has reported clinically significant outcomes in cancer patients. We defined MCID and evaluated the use of preoperative HRQoL for predicting MCID and survival after surgical resection of hepatocellular carcinoma (HCC). In total, 369 patients completed the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and the SF-36 at baseline and at two years post-operative at three tertiary academic hospitals. The corresponding MCID values were 3.6 (SF-36 physical component summary), 4.2 (SF-36 mental component summary), 5.4 (FACT-General total score), and 6.7 (FACT-Hep total score). The predictors of achieving postoperative MCID were significantly higher in patients who had low preoperative HRQoL score, advanced age, high education level, and high BMI (p < 0.05). However, patients with a high preoperative HRQoL score, high education level, high BMI, and low Charlson comorbidity index score were significantly associated with survival (p < 0.05). Preoperative HRQoL scores were predictive of MCID and overall survival after surgical resection of HCC. The findings of this study may be useful for managing the preoperative expectations of candidates for HCC resection and for developing shared decision-making procedures for patients undergoing surgical resection of HCC. MDPI 2019-04-27 /pmc/articles/PMC6572462/ /pubmed/31035539 http://dx.doi.org/10.3390/jcm8050576 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiu, Chong-Chi Lee, King-Teh Wang, Jhi-Joung Sun, Ding-Ping Lee, Hao-Hsien Huang, Chien-Cheng Shi, Hon-Yi Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title | Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title_full | Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title_fullStr | Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title_full_unstemmed | Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title_short | Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma |
title_sort | preoperative health-related quality of life predicts minimal clinically important difference and survival after surgical resection of hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572462/ https://www.ncbi.nlm.nih.gov/pubmed/31035539 http://dx.doi.org/10.3390/jcm8050576 |
work_keys_str_mv | AT chiuchongchi preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT leekingteh preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT wangjhijoung preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT sundingping preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT leehaohsien preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT huangchiencheng preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma AT shihonyi preoperativehealthrelatedqualityoflifepredictsminimalclinicallyimportantdifferenceandsurvivalaftersurgicalresectionofhepatocellularcarcinoma |