Cargando…

Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones

In the search for new anticancer agents, a library of variously substituted 3-methylidenechroman-4-ones was synthesized using Horner–Wadsworth–Emmons methodology. Acylation of diethyl methylphosphonate with selected ethyl salicylates furnished 3-diethoxyphosphorylchromen-4-ones which were next used...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kędzia, Jacek, Bartosik, Tomasz, Drogosz, Joanna, Janecka, Anna, Krajewska, Urszula, Janecki, Tomasz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572547/ https://www.ncbi.nlm.nih.gov/pubmed/31096601 http://dx.doi.org/10.3390/molecules24101868

Ejemplares similares

Synthesis of 2,2,6-Trisubstituted 5-Methylidene-tetrahydropyran-4-ones with Anticancer Activity †
por: Bartosik, Tomasz, et al.
Publicado: (2020)

Stereoselective Synthesis and Anticancer Activity of 2,6-Disubstituted trans-3-Methylidenetetrahydropyran-4-ones
por: Bartosik, Tomasz, et al.
Publicado: (2022)

Synthesis and Anticancer Properties of New 3-Methylidene-1-sulfonyl-2,3-dihydroquinolin-4(1H)-ones
por: Jaskulska, Agata, et al.
Publicado: (2022)

Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4,9-dione
por: Drogosz-Stachowicz, Joanna, et al.
Publicado: (2023)

Involvement of a coumarin analog AD-013 in the DNA damage response pathways in MCF-7 cells
por: Długosz, Angelika, et al.
Publicado: (2018)

New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line
por: Długosz-Pokorska, Angelika, et al.
Publicado: (2020)

A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells
por: Gach-Janczak, Katarzyna, et al.
Publicado: (2020)

Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines
por: Wyrębska, Anna, et al.
Publicado: (2012)

New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential
por: Pacuła, Agata J., et al.
Publicado: (2017)

New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF-7 Cancer Cells
por: Długosz-Pokorska, Angelika, et al.
Publicado: (2023)

Intramolecular C-N Bond Formation via Thermal Arene C-H Bond Activation Supported by Au(III) Complexes
por: Mruk, Julianna, et al.
Publicado: (2021)

Phenylselanyl Group Incorporation for “Glutathione Peroxidase-Like” Activity Modulation
por: Obieziurska-Fabisiak, Magdalena, et al.
Publicado: (2020)

Facile synthesis of chiral phenylselenides as novel antioxidants and cytotoxic agents
por: Laskowska, Anna, et al.
Publicado: (2023)

Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives
por: Yahia, Hamdi Ben, et al.
Publicado: (2020)

Synthesis and Cytotoxic Activity of Lepidilines A–D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones
por: Mlostoń, Grzegorz, et al.
Publicado: (2021)

Synthesis of Aromatic Retinoids and Curcuminoids and Evaluation of their Antiproliferative, Antiradical, and Anti‐inflammatory Activities
por: Morzycki, Jacek W., et al.
Publicado: (2016)

Synthesis and cytotoxic evaluation of some new[1,3]dioxolo[4,5-g]chromen-8-one derivatives
por: Alipour, Eskandar, et al.
Publicado: (2014)

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones
por: Kumar, Krishnan Suresh, et al.
Publicado: (2010)

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation
por: Pele, Raluca, et al.
Publicado: (2022)

Enhanced Cytotoxic Activity of PEGylated Curcumin Derivatives: Synthesis, Structure–Activity Evaluation, and Biological Activity
por: Lazewski, Dawid, et al.
Publicado: (2023)

Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7-methoxychroman-4-one derivatives
por: Noushini, Saeedeh, et al.
Publicado: (2013)

Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones
por: Kohatsu, Haruki, et al.
Publicado: (2020)

Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models
por: Bijak, Michal, et al.
Publicado: (2017)

Synthesis, antioxidant and cytoprotective activity evaluation of C-3 substituted indole derivatives
por: Jasiewicz, Beata, et al.
Publicado: (2021)

Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors
por: Wtorek, Karol, et al.
Publicado: (2019)

Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids
por: Trotsko, Nazar, et al.
Publicado: (2018)

Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
por: Zhang, Haiwen, et al.
Publicado: (2008)

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors
por: Janecka, Aleksandra, et al.
Publicado: (2023)

Modifications of Hydroxyapatite by Gallium and Silver Ions—Physicochemical Characterization, Cytotoxicity and Antibacterial Evaluation
por: Pajor, Kamil, et al.
Publicado: (2020)

Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects
por: Hosseinzadeh, Leila, et al.
Publicado: (2017)

An Evaluation of the DNA-Protective Effects of Extracts from Menyanthes trifoliata L. Plants Derived from In Vitro Culture Associated with Redox Balance and Other Biological Activities
por: Kowalczyk, Tomasz, et al.
Publicado: (2019)

Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β(3)-Lysine
por: Wtorek, Karol, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of 1,3-Diphenyl-3-(phenylthio)propan-1-ones as New Cytotoxic Agents
por: Bayanati, Maryam, et al.
Publicado: (2021)

Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents
por: Jean, Julie, et al.
Publicado: (2018)

One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
por: Gomha, Sobhi M., et al.
Publicado: (2016)

Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl]-3H-pyrido[2,3-d]pyrimidin-4-one derivatives
por: Rahmani Khajouei, Marzieh, et al.
Publicado: (2021)

Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives
por: Popiołek, Łukasz, et al.
Publicado: (2012)

Can we extrapolate the outcomes of in vitro studies on murine endothelium to studies of human platelet-endothelium interactions? A technical note
por: Golański, Jacek, et al.
Publicado: (2011)

Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
por: de Beer, Johannie, et al.
Publicado: (2020)

Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
por: Selvam, P., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_45p1i4qeg1aebnin3r0ls2cf53