Cargando…

Amantadine Combines Astroglial System Xc(−) Activation with Glutamate/NMDA Receptor Inhibition

A glutamate/NMDA receptor (NMDA-R) antagonist, amantadine (AMA) exhibits a broad spectrum of clinically important properties, including antiviral, antiparkinsonian, neuroprotective, neuro-reparative and cognitive-enhancing effects. However, both clinical and pre-clinical studies have demonstrated th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakano, Tomosuke, Hasegawa, Toshiki, Suzuki, Dai, Motomura, Eishi, Okada, Motohiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572554/ https://www.ncbi.nlm.nih.gov/pubmed/31108896 http://dx.doi.org/10.3390/biom9050191

Ejemplares similares

Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
por: Nakano, Tomosuke, et al.
Publicado: (2019)

Longitudinal Improvement of Neurocognition after Electroconvulsive Therapy in Bipolar Depression
por: Nakano, Tomosuke, et al.
Publicado: (2021)

Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems
por: Fukuyama, Kouji, et al.
Publicado: (2022)

Analysing the Impacts of Financial Support for Regional Suicide Prevention Programmes on Suicide Mortality Caused by Major Suicide Motives in Japan Using Statistical Government Data
por: Nakano, Tomosuke, et al.
Publicado: (2021)

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc(−)
por: Okada, Motohiro, et al.
Publicado: (2019)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

Brivaracetam and Levetiracetam Suppress Astroglial L-Glutamate Release through Hemichannel via Inhibition of Synaptic Vesicle Protein
por: Fukuyama, Kouji, et al.
Publicado: (2022)

Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43
por: Shiroyama, Takashi, et al.
Publicado: (2021)

Astroglial Glutamate Signaling and Uptake in the Hippocampus
por: Rose, Christine R., et al.
Publicado: (2018)

Carbamazepine Attenuates Astroglial L-Glutamate Release Induced by Pro-Inflammatory Cytokines via Chronically Activation of Adenosine A(2A) Receptor
por: Okada, Motohiro, et al.
Publicado: (2019)

Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity
por: Gajewski, Mariusz, et al.
Publicado: (2023)

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
por: Gallagher, Martin
Publicado: (2020)

Mechanical and Electronic Properties of XC(6) and XC(12)
por: Wei, Qun, et al.
Publicado: (2016)

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)
por: Parker, Joanne L., et al.
Publicado: (2021)

Rapid recycling of glutamate transporters on the astroglial surface
por: Michaluk, Piotr, et al.
Publicado: (2021)

Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study
por: Kawano, Yasuhiro, et al.
Publicado: (2021)

Dose-Dependent Biphasic Action of Quetiapine on AMPK Signalling via 5-HT7 Receptor: Exploring Pathophysiology of Clinical and Adverse Effects of Quetiapine
por: Okada, Motohiro, et al.
Publicado: (2022)

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions
por: Okada, Motohiro, et al.
Publicado: (2019)

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance
por: Cheung, Giselle, et al.
Publicado: (2015)

Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?
por: Lee, De-Hyung, et al.
Publicado: (2017)

New alleles of C. elegans gene cls-2 (R107.6), called xc3, xc4, and xc5
por: Munoz, Nicholas R., et al.
Publicado: (2017)

Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain
por: Fukuyama, Kouji, et al.
Publicado: (2023)

A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Impacts of Complete Unemployment Rates Disaggregated by Reason and Duration on Suicide Mortality from 2009–2022 in Japan
por: Matsumoto, Ryusuke, et al.
Publicado: (2023)

Non-empirical Mixing Coefficient for Hybrid XC Functionals from Analysis of the XC Kernel
por: Moldabekov, Zhandos A., et al.
Publicado: (2023)

Age-Dependent Astroglial Vulnerability to Hypoxia and Glutamate: The Role for Erythropoietin
por: Lourhmati, Ali, et al.
Publicado: (2013)

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii
por: Talman, William T., et al.
Publicado: (2017)

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor
por: Fukuyama, Kouji, et al.
Publicado: (2019)

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser
por: Okada, Motohiro, et al.
Publicado: (2020)

[(18)F]FDG PET signal is driven by astroglial glutamate transport
por: Zimmer, Eduardo R., et al.
Publicado: (2017)

Suicidal Mortality and Motives Among Middle-School, High-School, and University Students
por: Okada, Motohiro, et al.
Publicado: (2023)

Amantadine intoxication despite moderate renal dysfunction: A case of combined use with donepezil
por: Okada, Kouji, et al.
Publicado: (2020)

Programming PIC microcontrollers with XC8
por: Subero, Armstrong
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_26r1nol3hdp7s0oam4u0rklam8