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Development of a Ternary Solid Dispersion Formulation of LW6 to Improve the In Vivo Activity as a BCRP Inhibitor: Preparation and In Vitro/In Vivo Characterization

LW6 (3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-4-hydroxy-benzoic acid methyl ester) is a potent inhibitor of drug efflux by the breast cancer resistance protein (BCRP). However, its poor aqueous solubility leads to low bioavailability, which currently limits in vivo applications. Therefore, the p...

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Detalles Bibliográficos
Autores principales:	Bajracharya, Rajiv, Lee, Sang Hoon, Song, Jae Geun, Kim, Minkyoung, Lee, Kyeong, Han, Hyo-Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572573/ https://www.ncbi.nlm.nih.gov/pubmed/31052438 http://dx.doi.org/10.3390/pharmaceutics11050206

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