Cargando…
UPR: An Upstream Signal to EMT Induction in Cancer
The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stres...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572589/ https://www.ncbi.nlm.nih.gov/pubmed/31071975 http://dx.doi.org/10.3390/jcm8050624 |
_version_ | 1783427675758526464 |
---|---|
author | Santamaría, Patricia G. Mazón, María J. Eraso, Pilar Portillo, Francisco |
author_facet | Santamaría, Patricia G. Mazón, María J. Eraso, Pilar Portillo, Francisco |
author_sort | Santamaría, Patricia G. |
collection | PubMed |
description | The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stress, cells evoke an adaptive signalling network, the unfolded protein response (UPR), aimed at recovering protein homeostasis. Tumour cells must confront intrinsic and extrinsic pressures during cancer progression that produce a proteostasis imbalance and ER stress. To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. UPR activation has been documented in most types of human tumours and accumulating evidence supports a crucial role for UPR in the establishment, progression, metastasis and chemoresistance of tumours as well as its involvement in the acquisition of other hallmarks of cancer. In this review, we will analyse the role of UPR in cancer development highlighting the ability of tumours to exploit UPR signalling to promote epithelial-mesenchymal transition (EMT). |
format | Online Article Text |
id | pubmed-6572589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65725892019-06-18 UPR: An Upstream Signal to EMT Induction in Cancer Santamaría, Patricia G. Mazón, María J. Eraso, Pilar Portillo, Francisco J Clin Med Review The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stress, cells evoke an adaptive signalling network, the unfolded protein response (UPR), aimed at recovering protein homeostasis. Tumour cells must confront intrinsic and extrinsic pressures during cancer progression that produce a proteostasis imbalance and ER stress. To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. UPR activation has been documented in most types of human tumours and accumulating evidence supports a crucial role for UPR in the establishment, progression, metastasis and chemoresistance of tumours as well as its involvement in the acquisition of other hallmarks of cancer. In this review, we will analyse the role of UPR in cancer development highlighting the ability of tumours to exploit UPR signalling to promote epithelial-mesenchymal transition (EMT). MDPI 2019-05-08 /pmc/articles/PMC6572589/ /pubmed/31071975 http://dx.doi.org/10.3390/jcm8050624 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Santamaría, Patricia G. Mazón, María J. Eraso, Pilar Portillo, Francisco UPR: An Upstream Signal to EMT Induction in Cancer |
title | UPR: An Upstream Signal to EMT Induction in Cancer |
title_full | UPR: An Upstream Signal to EMT Induction in Cancer |
title_fullStr | UPR: An Upstream Signal to EMT Induction in Cancer |
title_full_unstemmed | UPR: An Upstream Signal to EMT Induction in Cancer |
title_short | UPR: An Upstream Signal to EMT Induction in Cancer |
title_sort | upr: an upstream signal to emt induction in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572589/ https://www.ncbi.nlm.nih.gov/pubmed/31071975 http://dx.doi.org/10.3390/jcm8050624 |
work_keys_str_mv | AT santamariapatriciag upranupstreamsignaltoemtinductionincancer AT mazonmariaj upranupstreamsignaltoemtinductionincancer AT erasopilar upranupstreamsignaltoemtinductionincancer AT portillofrancisco upranupstreamsignaltoemtinductionincancer |