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The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile

When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed...

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Autores principales: Christiansen, Lasse, Thomas, Richard, Beck, Mikkel M., Pingel, Jessica, Andersen, Jeppe D., Mang, Cameron S., Madsen, Mads A. J., Roig, Marc, Lundbye-Jensen, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572639/
https://www.ncbi.nlm.nih.gov/pubmed/31035583
http://dx.doi.org/10.3390/jcm8050578
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author Christiansen, Lasse
Thomas, Richard
Beck, Mikkel M.
Pingel, Jessica
Andersen, Jeppe D.
Mang, Cameron S.
Madsen, Mads A. J.
Roig, Marc
Lundbye-Jensen, Jesper
author_facet Christiansen, Lasse
Thomas, Richard
Beck, Mikkel M.
Pingel, Jessica
Andersen, Jeppe D.
Mang, Cameron S.
Madsen, Mads A. J.
Roig, Marc
Lundbye-Jensen, Jesper
author_sort Christiansen, Lasse
collection PubMed
description When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.
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spelling pubmed-65726392019-06-18 The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile Christiansen, Lasse Thomas, Richard Beck, Mikkel M. Pingel, Jessica Andersen, Jeppe D. Mang, Cameron S. Madsen, Mads A. J. Roig, Marc Lundbye-Jensen, Jesper J Clin Med Brief Report When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations. MDPI 2019-04-27 /pmc/articles/PMC6572639/ /pubmed/31035583 http://dx.doi.org/10.3390/jcm8050578 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Christiansen, Lasse
Thomas, Richard
Beck, Mikkel M.
Pingel, Jessica
Andersen, Jeppe D.
Mang, Cameron S.
Madsen, Mads A. J.
Roig, Marc
Lundbye-Jensen, Jesper
The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title_full The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title_fullStr The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title_full_unstemmed The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title_short The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
title_sort beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572639/
https://www.ncbi.nlm.nih.gov/pubmed/31035583
http://dx.doi.org/10.3390/jcm8050578
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