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Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population

PURPOSE: IL-7/IL-7R axis participates in the initiation and progression of lung cancer (LC). This study aimed to explore the potential influence of IL-7/IL-7R polymorphisms on LC risk. PATIENTS AND METHODS: In total, 1,010 participants (507 LC patients and 503 healthy controls) were enrolled. Five s...

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Autores principales: Zhang, Chan, Su, Pincan, Chen, Wanlu, Li, Qi, Dai, Run, Cheng, YuJing, Yang, Jiangcun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572729/
https://www.ncbi.nlm.nih.gov/pubmed/31354347
http://dx.doi.org/10.2147/CMAR.S202839
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author Zhang, Chan
Su, Pincan
Chen, Wanlu
Li, Qi
Dai, Run
Cheng, YuJing
Yang, Jiangcun
author_facet Zhang, Chan
Su, Pincan
Chen, Wanlu
Li, Qi
Dai, Run
Cheng, YuJing
Yang, Jiangcun
author_sort Zhang, Chan
collection PubMed
description PURPOSE: IL-7/IL-7R axis participates in the initiation and progression of lung cancer (LC). This study aimed to explore the potential influence of IL-7/IL-7R polymorphisms on LC risk. PATIENTS AND METHODS: In total, 1,010 participants (507 LC patients and 503 healthy controls) were enrolled. Five single-nucleotide polymorphisms (SNPs) in IL-7R and one SNP in IL-7 were genotyped in included samples with Agena MassARRAY system. OR and 95% CIs were computed by logistic regression analysis after adjusting for age and gender. Stratified analyses with demographic and clinical characteristics were also performed. Finally, linkage disequilibrium (LD) analysis was conducted with the PLINK version 1.07 software . RESULTS: IL-7R rs10053847 variant was related to a decreased LC risk under the allele gene (OR =0.78, P=0.043) and additive model (OR =0.77, P=0.042). The results of stratified analysis indicated that this SNP was associated with a lower LC risk among nonsmokers (AA/GG: OR =0.09, P=0.033; AA/AG+GG: OR =0.10 P=0.037) or nondrinkers (AA/GG: OR =0.07, P=0.047; AA/AG+GG: OR =0.18 P=0.049). Moreover, carriers of IL-7R rs10213865-C allele had an increased lung adenocarcinoma risk (CA/AA: OR =1.60, P=0.011; CC+CA/AA: OR =1.62, P=0.007; CA/CA/AA: OR =1.50, P=0.007). Additionally, AGAA haplotype (rs10213865, rs969129, rs118137916 and rs10053847) increased LC risk (OR =1.30, P=0.041). CONCLUSION: IL-7R rs10053847 was correlated with a decreased LC risk, while IL-7R rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation.
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spelling pubmed-65727292019-07-26 Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population Zhang, Chan Su, Pincan Chen, Wanlu Li, Qi Dai, Run Cheng, YuJing Yang, Jiangcun Cancer Manag Res Original Research PURPOSE: IL-7/IL-7R axis participates in the initiation and progression of lung cancer (LC). This study aimed to explore the potential influence of IL-7/IL-7R polymorphisms on LC risk. PATIENTS AND METHODS: In total, 1,010 participants (507 LC patients and 503 healthy controls) were enrolled. Five single-nucleotide polymorphisms (SNPs) in IL-7R and one SNP in IL-7 were genotyped in included samples with Agena MassARRAY system. OR and 95% CIs were computed by logistic regression analysis after adjusting for age and gender. Stratified analyses with demographic and clinical characteristics were also performed. Finally, linkage disequilibrium (LD) analysis was conducted with the PLINK version 1.07 software . RESULTS: IL-7R rs10053847 variant was related to a decreased LC risk under the allele gene (OR =0.78, P=0.043) and additive model (OR =0.77, P=0.042). The results of stratified analysis indicated that this SNP was associated with a lower LC risk among nonsmokers (AA/GG: OR =0.09, P=0.033; AA/AG+GG: OR =0.10 P=0.037) or nondrinkers (AA/GG: OR =0.07, P=0.047; AA/AG+GG: OR =0.18 P=0.049). Moreover, carriers of IL-7R rs10213865-C allele had an increased lung adenocarcinoma risk (CA/AA: OR =1.60, P=0.011; CC+CA/AA: OR =1.62, P=0.007; CA/CA/AA: OR =1.50, P=0.007). Additionally, AGAA haplotype (rs10213865, rs969129, rs118137916 and rs10053847) increased LC risk (OR =1.30, P=0.041). CONCLUSION: IL-7R rs10053847 was correlated with a decreased LC risk, while IL-7R rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation. Dove 2019-06-11 /pmc/articles/PMC6572729/ /pubmed/31354347 http://dx.doi.org/10.2147/CMAR.S202839 Text en © 2019 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Chan
Su, Pincan
Chen, Wanlu
Li, Qi
Dai, Run
Cheng, YuJing
Yang, Jiangcun
Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title_full Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title_fullStr Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title_full_unstemmed Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title_short Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population
title_sort genetic polymorphisms in il-7 and il-7r are correlated with lung cancer risk in the chinese han population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572729/
https://www.ncbi.nlm.nih.gov/pubmed/31354347
http://dx.doi.org/10.2147/CMAR.S202839
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