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The dark side of technological advances in analysis of microbial ecosystems
Recent technological advances mean that samples from animal experiments may be analysed more cheaply, more easily and with a much greater return of data than previously. Research groups are frequently faced with a choice of continuing to use established technology in which they may have made a signi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572749/ https://www.ncbi.nlm.nih.gov/pubmed/31236270 http://dx.doi.org/10.1186/s40104-019-0357-2 |
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author | Bailey, Mick Thomas, Amy Francis, Ore Stokes, Christopher Smidt, Hauke |
author_facet | Bailey, Mick Thomas, Amy Francis, Ore Stokes, Christopher Smidt, Hauke |
author_sort | Bailey, Mick |
collection | PubMed |
description | Recent technological advances mean that samples from animal experiments may be analysed more cheaply, more easily and with a much greater return of data than previously. Research groups are frequently faced with a choice of continuing to use established technology in which they may have made a significant investment of time and resources, and have significant amounts of reference data, or switching to new technology where reference data may be limited. Apart from cost, the choice needs to be based on a comparison between the increase in data available from future experiments by switching and the value of comparison with reference data from historical experiments analysed with earlier technology. One approach to this problem is to ensure that sufficient quantity and variety of samples are taken from each experiment and appropriately stored to allow re-establishment of a sufficiently large reference set and to avoid the need to repeat animal experiments. The establishment of ‘biobanks’ of experimental material will require funding for infrastructure, consistent storage of metadata and, importantly, horizon-scanning to ensure that samples are taken appropriately for techniques which will become accessible in future. Such biobanks are a recognised resource in human medicine, where the value of samples increases as more analysis is carried out and added to the metadata. |
format | Online Article Text |
id | pubmed-6572749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65727492019-06-24 The dark side of technological advances in analysis of microbial ecosystems Bailey, Mick Thomas, Amy Francis, Ore Stokes, Christopher Smidt, Hauke J Anim Sci Biotechnol Review Recent technological advances mean that samples from animal experiments may be analysed more cheaply, more easily and with a much greater return of data than previously. Research groups are frequently faced with a choice of continuing to use established technology in which they may have made a significant investment of time and resources, and have significant amounts of reference data, or switching to new technology where reference data may be limited. Apart from cost, the choice needs to be based on a comparison between the increase in data available from future experiments by switching and the value of comparison with reference data from historical experiments analysed with earlier technology. One approach to this problem is to ensure that sufficient quantity and variety of samples are taken from each experiment and appropriately stored to allow re-establishment of a sufficiently large reference set and to avoid the need to repeat animal experiments. The establishment of ‘biobanks’ of experimental material will require funding for infrastructure, consistent storage of metadata and, importantly, horizon-scanning to ensure that samples are taken appropriately for techniques which will become accessible in future. Such biobanks are a recognised resource in human medicine, where the value of samples increases as more analysis is carried out and added to the metadata. BioMed Central 2019-06-17 /pmc/articles/PMC6572749/ /pubmed/31236270 http://dx.doi.org/10.1186/s40104-019-0357-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Bailey, Mick Thomas, Amy Francis, Ore Stokes, Christopher Smidt, Hauke The dark side of technological advances in analysis of microbial ecosystems |
title | The dark side of technological advances in analysis of microbial ecosystems |
title_full | The dark side of technological advances in analysis of microbial ecosystems |
title_fullStr | The dark side of technological advances in analysis of microbial ecosystems |
title_full_unstemmed | The dark side of technological advances in analysis of microbial ecosystems |
title_short | The dark side of technological advances in analysis of microbial ecosystems |
title_sort | dark side of technological advances in analysis of microbial ecosystems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572749/ https://www.ncbi.nlm.nih.gov/pubmed/31236270 http://dx.doi.org/10.1186/s40104-019-0357-2 |
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