Domain-interface dynamics of CFTR revealed by stabilizing nanobodies

The leading cause of cystic fibrosis (CF) is the deletion of phenylalanine 508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutation affects the thermodynamic stability of the domain and the integrity of the interface...

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Detalles Bibliográficos
Autores principales: Sigoillot, Maud, Overtus, Marie, Grodecka, Magdalena, Scholl, Daniel, Garcia-Pino, Abel, Laeremans, Toon, He, Lihua, Pardon, Els, Hildebrandt, Ellen, Urbatsch, Ina, Steyaert, Jan, Riordan, John R., Govaerts, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572788/
https://www.ncbi.nlm.nih.gov/pubmed/31201318
http://dx.doi.org/10.1038/s41467-019-10714-y

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