Cargando…

C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

The transcription factors LAP1, LAP2 and LIP are derived from the Cebpb-mRNA through the use of alternative start codons. High LIP expression has been associated with human cancer and increased cancer incidence in mice. However, how LIP contributes to cellular transformation is poorly understood. He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ackermann, Tobias, Hartleben, Götz, Müller, Christine, Mastrobuoni, Guido, Groth, Marco, Sterken, Britt A., Zaini, Mohamad A., Youssef, Sameh A., Zuidhof, Hidde R., Krauss, Sara R., Kortman, Gertrud, de Haan, Gerald, de Bruin, Alain, Wang, Zhao-Qi, Platzer, Matthias, Kempa, Stefan, Calkhoven, Cornelis F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572810/ https://www.ncbi.nlm.nih.gov/pubmed/31240246 http://dx.doi.org/10.1038/s42003-019-0461-z

Ejemplares similares

C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition
por: Ackermann, Tobias, et al.
Publicado: (2023)

C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells
por: Sterken, Britt A., et al.
Publicado: (2022)

A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties
por: Zaini, Mohamad A., et al.
Publicado: (2017)

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice
por: Zidek, Laura M, et al.
Publicado: (2015)

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
por: Müller, Christine, et al.
Publicado: (2018)

Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding
por: Müller, Christine, et al.
Publicado: (2022)

Shwachman–Bodian–Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs
por: In, Kyungmin, et al.
Publicado: (2016)

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
por: Graf, Robin, et al.
Publicado: (2013)

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7
por: Gauthier, Kimberley D., et al.
Publicado: (2021)

The LIN28/let-7 Pathway in Cancer
por: Balzeau, Julien, et al.
Publicado: (2017)

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2019)

Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma
por: Hartleben, Götz, et al.
Publicado: (2018)

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
por: Gökbuget, Deniz, et al.
Publicado: (2015)

The Role of LIN28-let-7-ARID3B Pathway in Placental Development
por: Ali, Asghar, et al.
Publicado: (2020)

Author Correction: Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2020)

Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development
por: Ali, Asghar, et al.
Publicado: (2022)

LIN28B and Let-7 in Diffuse Midline Glioma: A Review
por: Knowles, Truman, et al.
Publicado: (2023)

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28
por: Wang, Longfei, et al.
Publicado: (2018)

A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7
por: Yu, Chunxiao, et al.
Publicado: (2020)

Nucleolar retention of a translational C/EBPα isoform stimulates rDNA transcription and cell size
por: Müller, Christine, et al.
Publicado: (2010)

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
por: Wang, Tianzhen, et al.
Publicado: (2015)

The Lin28 cold-shock domain remodels pre-let-7 microRNA
por: Mayr, Florian, et al.
Publicado: (2012)

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
por: Madison, Blair B., et al.
Publicado: (2013)

The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy
por: Lozoya, Teresa, et al.
Publicado: (2014)

Bistable Switch in let-7 miRNA Biogenesis Pathway Involving Lin28
por: Shi, Fei, et al.
Publicado: (2014)

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis
por: Bhattacharya, Debadrita, et al.
Publicado: (2018)

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
por: Lightfoot, Helen L., et al.
Publicado: (2016)

Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
por: Faehnle, Christopher R., et al.
Publicado: (2014)

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway
por: Pérez, Laura M., et al.
Publicado: (2013)

The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma
por: Manier, Salomon, et al.
Publicado: (2016)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells
por: Roos, Martina, et al.
Publicado: (2015)

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7–Lin28 RNA–Protein Interaction
por: Lorenz, Daniel A., et al.
Publicado: (2018)

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
por: Wang, Dahai, et al.
Publicado: (2022)

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival
por: Shahab, Shubin W., et al.
Publicado: (2023)

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells
por: Hagan, John P., et al.
Publicado: (2009)

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors
por: Desjardins, Alexandre, et al.
Publicado: (2014)

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
por: Lozier, Ann M., et al.
Publicado: (2014)

A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B
por: Suzuki, Hiroshi I, et al.
Publicado: (2015)

Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
por: Rowe, R. Grant, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_la9avsnra2379mhfm5e99v4ae2