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Photoacoustics can image spreading depolarization deep in gyrencephalic brain

Spreading depolarization (SD) is a self-propagating wave of near-complete neuronal depolarization that is abundant in a wide range of neurological conditions, including stroke. SD was only recently documented in humans and is now considered a therapeutic target for brain injury, but the mechanisms r...

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Autores principales: Kirchner, Thomas, Gröhl, Janek, Herrera, Mildred A., Adler, Tim, Hernández-Aguilera, Adrián, Santos, Edgar, Maier-Hein, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572820/
https://www.ncbi.nlm.nih.gov/pubmed/31209253
http://dx.doi.org/10.1038/s41598-019-44935-4
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author Kirchner, Thomas
Gröhl, Janek
Herrera, Mildred A.
Adler, Tim
Hernández-Aguilera, Adrián
Santos, Edgar
Maier-Hein, Lena
author_facet Kirchner, Thomas
Gröhl, Janek
Herrera, Mildred A.
Adler, Tim
Hernández-Aguilera, Adrián
Santos, Edgar
Maier-Hein, Lena
author_sort Kirchner, Thomas
collection PubMed
description Spreading depolarization (SD) is a self-propagating wave of near-complete neuronal depolarization that is abundant in a wide range of neurological conditions, including stroke. SD was only recently documented in humans and is now considered a therapeutic target for brain injury, but the mechanisms related to SD in complex brains are not well understood. While there are numerous approaches to interventional imaging of SD on the exposed brain surface, measuring SD deep in brain is so far only possible with low spatiotemporal resolution and poor contrast. Here, we show that photoacoustic imaging enables the study of SD and its hemodynamics deep in the gyrencephalic brain with high spatiotemporal resolution. As rapid neuronal depolarization causes tissue hypoxia, we achieve this by continuously estimating blood oxygenation with an intraoperative hybrid photoacoustic and ultrasonic imaging system. Due to its high resolution, promising imaging depth and high contrast, this novel approach to SD imaging can yield new insights into SD and thereby lead to advances in stroke, and brain injury research.
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spelling pubmed-65728202019-06-24 Photoacoustics can image spreading depolarization deep in gyrencephalic brain Kirchner, Thomas Gröhl, Janek Herrera, Mildred A. Adler, Tim Hernández-Aguilera, Adrián Santos, Edgar Maier-Hein, Lena Sci Rep Article Spreading depolarization (SD) is a self-propagating wave of near-complete neuronal depolarization that is abundant in a wide range of neurological conditions, including stroke. SD was only recently documented in humans and is now considered a therapeutic target for brain injury, but the mechanisms related to SD in complex brains are not well understood. While there are numerous approaches to interventional imaging of SD on the exposed brain surface, measuring SD deep in brain is so far only possible with low spatiotemporal resolution and poor contrast. Here, we show that photoacoustic imaging enables the study of SD and its hemodynamics deep in the gyrencephalic brain with high spatiotemporal resolution. As rapid neuronal depolarization causes tissue hypoxia, we achieve this by continuously estimating blood oxygenation with an intraoperative hybrid photoacoustic and ultrasonic imaging system. Due to its high resolution, promising imaging depth and high contrast, this novel approach to SD imaging can yield new insights into SD and thereby lead to advances in stroke, and brain injury research. Nature Publishing Group UK 2019-06-17 /pmc/articles/PMC6572820/ /pubmed/31209253 http://dx.doi.org/10.1038/s41598-019-44935-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kirchner, Thomas
Gröhl, Janek
Herrera, Mildred A.
Adler, Tim
Hernández-Aguilera, Adrián
Santos, Edgar
Maier-Hein, Lena
Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title_full Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title_fullStr Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title_full_unstemmed Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title_short Photoacoustics can image spreading depolarization deep in gyrencephalic brain
title_sort photoacoustics can image spreading depolarization deep in gyrencephalic brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572820/
https://www.ncbi.nlm.nih.gov/pubmed/31209253
http://dx.doi.org/10.1038/s41598-019-44935-4
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