Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Enormous efforts have been made to target metabolic dependencies of cancer cells for developing new therapies. However, the therapeutic efficacy of glycolysis inhibitors is limited due to their inability to elicit cell death. Hexokinase 2 (HK2), via its mitochondrial localization, functions as a cen...

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Detalles Bibliográficos
Autores principales: Lee, Hong-Jen, Li, Chien-Feng, Ruan, Diane, He, Jiabei, Montal, Emily D., Lorenz, Sonja, Girnun, Geoffrey D., Chan, Chia-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573064/
https://www.ncbi.nlm.nih.gov/pubmed/31201299
http://dx.doi.org/10.1038/s41467-019-10374-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573064/
https://www.ncbi.nlm.nih.gov/pubmed/31201299
http://dx.doi.org/10.1038/s41467-019-10374-y

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