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Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women

Purpose: Nonalcoholic fatty liver disease (NAFLD) is often referred to as the hepatic manifestation of the metabolic syndrome. The relationship between body weight, NAFLD, and insulin resistance is not well characterized in humans. Additionally, it is unclear why South Asians develop these complicat...

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Autores principales: Albracht-Schulte, Kembra, Rosairo, Shanthini, Ramalingam, Latha, Wijetunge, Sulochana, Ratnayake, RMCJ, Kotakadeniya, HMSRB, Dawson, John A, Kalupahana, Nishan S, Moustaid-Moussa, Naima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573778/
https://www.ncbi.nlm.nih.gov/pubmed/31354322
http://dx.doi.org/10.2147/DMSO.S203937
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author Albracht-Schulte, Kembra
Rosairo, Shanthini
Ramalingam, Latha
Wijetunge, Sulochana
Ratnayake, RMCJ
Kotakadeniya, HMSRB
Dawson, John A
Kalupahana, Nishan S
Moustaid-Moussa, Naima
author_facet Albracht-Schulte, Kembra
Rosairo, Shanthini
Ramalingam, Latha
Wijetunge, Sulochana
Ratnayake, RMCJ
Kotakadeniya, HMSRB
Dawson, John A
Kalupahana, Nishan S
Moustaid-Moussa, Naima
author_sort Albracht-Schulte, Kembra
collection PubMed
description Purpose: Nonalcoholic fatty liver disease (NAFLD) is often referred to as the hepatic manifestation of the metabolic syndrome. The relationship between body weight, NAFLD, and insulin resistance is not well characterized in humans. Additionally, it is unclear why South Asians develop these complications at lower levels of obesity compared to their Western counterparts. Patients and methods: To address this question, we performed a cross-sectional study using a convenience sample of Sri Lankan adult females (n=34) and collected anthropometric data, adipose tissue specimens (for histology), and fasted serum samples (for metabolic and inflammatory markers). Hepatic steatosis was assessed by ultrasound scanning and used to classify participants as NAFL 0, NAFL 1, and NAFL 2. Results: Waist circumference significantly increased with increasing NAFL grade. Participants with NAFL had significantly higher body mass index, hip circumference, and fasting plasma glucose, as well as a higher mean adipocyte area in both abdominal subcutaneous and visceral areas, indicating a higher degree of adipocyte hypertrophy associated with fatty liver. There were, however, no differences in measures of dyslipidemia. Of the multiple adipokines measured, resistin was the only proinflammatory adipokine significantly elevated in NAFL 2. Conclusion: These findings indicate that measures of adiposity, fasting serum glucose, and resistin may be important indicators of NAFLD in South Asian women.
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spelling pubmed-65737782019-07-26 Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women Albracht-Schulte, Kembra Rosairo, Shanthini Ramalingam, Latha Wijetunge, Sulochana Ratnayake, RMCJ Kotakadeniya, HMSRB Dawson, John A Kalupahana, Nishan S Moustaid-Moussa, Naima Diabetes Metab Syndr Obes Original Research Purpose: Nonalcoholic fatty liver disease (NAFLD) is often referred to as the hepatic manifestation of the metabolic syndrome. The relationship between body weight, NAFLD, and insulin resistance is not well characterized in humans. Additionally, it is unclear why South Asians develop these complications at lower levels of obesity compared to their Western counterparts. Patients and methods: To address this question, we performed a cross-sectional study using a convenience sample of Sri Lankan adult females (n=34) and collected anthropometric data, adipose tissue specimens (for histology), and fasted serum samples (for metabolic and inflammatory markers). Hepatic steatosis was assessed by ultrasound scanning and used to classify participants as NAFL 0, NAFL 1, and NAFL 2. Results: Waist circumference significantly increased with increasing NAFL grade. Participants with NAFL had significantly higher body mass index, hip circumference, and fasting plasma glucose, as well as a higher mean adipocyte area in both abdominal subcutaneous and visceral areas, indicating a higher degree of adipocyte hypertrophy associated with fatty liver. There were, however, no differences in measures of dyslipidemia. Of the multiple adipokines measured, resistin was the only proinflammatory adipokine significantly elevated in NAFL 2. Conclusion: These findings indicate that measures of adiposity, fasting serum glucose, and resistin may be important indicators of NAFLD in South Asian women. Dove 2019-06-10 /pmc/articles/PMC6573778/ /pubmed/31354322 http://dx.doi.org/10.2147/DMSO.S203937 Text en © 2019 Albracht-Schulte et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Albracht-Schulte, Kembra
Rosairo, Shanthini
Ramalingam, Latha
Wijetunge, Sulochana
Ratnayake, RMCJ
Kotakadeniya, HMSRB
Dawson, John A
Kalupahana, Nishan S
Moustaid-Moussa, Naima
Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title_full Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title_fullStr Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title_full_unstemmed Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title_short Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women
title_sort obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in south asian women
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573778/
https://www.ncbi.nlm.nih.gov/pubmed/31354322
http://dx.doi.org/10.2147/DMSO.S203937
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