CD22 blockade restores homeostatic microglial phagocytosis in aging brains

Microglia maintain homeostasis in the central nervous system (CNS) through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during aging and neurodegenerative disease, concomitant with cognitive decline. However, the mechanisms of impaired microglial homeost...

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Detalles Bibliográficos
Autores principales: Pluvinage, John V., Haney, Michael S., Smith, Benjamin A. H., Sun, Jerry, Iram, Tal, Bonanno, Liana, Li, Lulin, Lee, Davis P., Morgens, David W., Yang, Andrew C., Shuken, Steven R., Gate, David, Scott, Madeleine, Khatri, Purvesh, Luo, Jian, Bertozzi, Carolyn R., Bassik, Michael C., Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574119/
https://www.ncbi.nlm.nih.gov/pubmed/30944478
http://dx.doi.org/10.1038/s41586-019-1088-4

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