Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury

Mifepristone is frequently used in large doses for management of Cushing’s syndrome. This is a case of a 35-year-old woman with Cushing’s syndrome, who presented with abdominal pain and jaundice. A month prior to admission, she had been started on a daily dose of 1,200 mg mifepristone. After evaluat...

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Detalles Bibliográficos
Autores principales: Shah, Ishani, Putnam, Tyler, Daugherty, Evan, Vyas, Neil, Chuang, Keng-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575131/
https://www.ncbi.nlm.nih.gov/pubmed/31236162
http://dx.doi.org/10.14740/gr1188
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author Shah, Ishani
Putnam, Tyler
Daugherty, Evan
Vyas, Neil
Chuang, Keng-Yu
author_facet Shah, Ishani
Putnam, Tyler
Daugherty, Evan
Vyas, Neil
Chuang, Keng-Yu
author_sort Shah, Ishani
collection PubMed
description Mifepristone is frequently used in large doses for management of Cushing’s syndrome. This is a case of a 35-year-old woman with Cushing’s syndrome, who presented with abdominal pain and jaundice. A month prior to admission, she had been started on a daily dose of 1,200 mg mifepristone. After evaluating for various other causes of liver injury, biopsy revealed cholestatic pattern of liver disease, likely associated with drug-induced hepatotoxicity. Mifepristone was discontinued and her symptoms resolved. We believe this is one of the first few reported cases of drug-induced liver injury (DILI) associated with mifepristone use.
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spelling pubmed-65751312019-06-24 Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury Shah, Ishani Putnam, Tyler Daugherty, Evan Vyas, Neil Chuang, Keng-Yu Gastroenterology Res Case Report Mifepristone is frequently used in large doses for management of Cushing’s syndrome. This is a case of a 35-year-old woman with Cushing’s syndrome, who presented with abdominal pain and jaundice. A month prior to admission, she had been started on a daily dose of 1,200 mg mifepristone. After evaluating for various other causes of liver injury, biopsy revealed cholestatic pattern of liver disease, likely associated with drug-induced hepatotoxicity. Mifepristone was discontinued and her symptoms resolved. We believe this is one of the first few reported cases of drug-induced liver injury (DILI) associated with mifepristone use. Elmer Press 2019-06 2019-06-07 /pmc/articles/PMC6575131/ /pubmed/31236162 http://dx.doi.org/10.14740/gr1188 Text en Copyright 2019, Shah et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shah, Ishani
Putnam, Tyler
Daugherty, Evan
Vyas, Neil
Chuang, Keng-Yu
Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title_full Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title_fullStr Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title_full_unstemmed Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title_short Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
title_sort mifepristone: an uncommon cause of drug-induced liver injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575131/
https://www.ncbi.nlm.nih.gov/pubmed/31236162
http://dx.doi.org/10.14740/gr1188
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AT vyasneil mifepristoneanuncommoncauseofdruginducedliverinjury
AT chuangkengyu mifepristoneanuncommoncauseofdruginducedliverinjury

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