Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Antigen binding by serum Ig-M (IgM) protects against microbial infections and helps to prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen-bound IgM activates complement-immune responses remains unclear. We present cryoelectron tomography structures of IgM, C1, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharp, Thomas H., Boyle, Aimee L., Diebolder, Christoph A., Kros, Alexander, Koster, Abraham J., Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575175/
https://www.ncbi.nlm.nih.gov/pubmed/31147461
http://dx.doi.org/10.1073/pnas.1901841116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575175/
https://www.ncbi.nlm.nih.gov/pubmed/31147461
http://dx.doi.org/10.1073/pnas.1901841116

Ejemplares similares