Photocontrollable mononegaviruses

Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generate...

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Detalles Bibliográficos
Autores principales: Tahara, Maino, Takishima, Yuto, Miyamoto, Shohei, Nakatsu, Yuichiro, Someya, Kenji, Sato, Moritoshi, Tani, Kenzaburo, Takeda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575177/
https://www.ncbi.nlm.nih.gov/pubmed/31138700
http://dx.doi.org/10.1073/pnas.1906531116
Descripción
Sumario:Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.

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