Photocontrollable mononegaviruses

Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generate...

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Detalles Bibliográficos
Autores principales: Tahara, Maino, Takishima, Yuto, Miyamoto, Shohei, Nakatsu, Yuichiro, Someya, Kenji, Sato, Moritoshi, Tani, Kenzaburo, Takeda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575177/
https://www.ncbi.nlm.nih.gov/pubmed/31138700
http://dx.doi.org/10.1073/pnas.1906531116
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author Tahara, Maino
Takishima, Yuto
Miyamoto, Shohei
Nakatsu, Yuichiro
Someya, Kenji
Sato, Moritoshi
Tani, Kenzaburo
Takeda, Makoto
author_facet Tahara, Maino
Takishima, Yuto
Miyamoto, Shohei
Nakatsu, Yuichiro
Someya, Kenji
Sato, Moritoshi
Tani, Kenzaburo
Takeda, Makoto
author_sort Tahara, Maino
collection PubMed
description Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.
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spelling pubmed-65751772019-06-21 Photocontrollable mononegaviruses Tahara, Maino Takishima, Yuto Miyamoto, Shohei Nakatsu, Yuichiro Someya, Kenji Sato, Moritoshi Tani, Kenzaburo Takeda, Makoto Proc Natl Acad Sci U S A Biological Sciences Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination. National Academy of Sciences 2019-06-11 2019-05-28 /pmc/articles/PMC6575177/ /pubmed/31138700 http://dx.doi.org/10.1073/pnas.1906531116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Tahara, Maino
Takishima, Yuto
Miyamoto, Shohei
Nakatsu, Yuichiro
Someya, Kenji
Sato, Moritoshi
Tani, Kenzaburo
Takeda, Makoto
Photocontrollable mononegaviruses
title Photocontrollable mononegaviruses
title_full Photocontrollable mononegaviruses
title_fullStr Photocontrollable mononegaviruses
title_full_unstemmed Photocontrollable mononegaviruses
title_short Photocontrollable mononegaviruses
title_sort photocontrollable mononegaviruses
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575177/
https://www.ncbi.nlm.nih.gov/pubmed/31138700
http://dx.doi.org/10.1073/pnas.1906531116
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