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Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study

OBJECTIVE: To examine the effect of smoking on risk of atherosclerotic cardiovascular disease (ASCVD) in Korean young men and to examine whether serum total cholesterol levels could modify the effect of smoking on ASCVD. DESIGN: A prospective cohort study within a national insurance system. SETTING:...

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Autores principales: Jee, Yongho, Jung, Keum Ji, Lee, Sunmi, Back, Joung Hwan, Jee, Sun Ha, Cho, Sung-il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575821/
https://www.ncbi.nlm.nih.gov/pubmed/31196897
http://dx.doi.org/10.1136/bmjopen-2018-024453
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author Jee, Yongho
Jung, Keum Ji
Lee, Sunmi
Back, Joung Hwan
Jee, Sun Ha
Cho, Sung-il
author_facet Jee, Yongho
Jung, Keum Ji
Lee, Sunmi
Back, Joung Hwan
Jee, Sun Ha
Cho, Sung-il
author_sort Jee, Yongho
collection PubMed
description OBJECTIVE: To examine the effect of smoking on risk of atherosclerotic cardiovascular disease (ASCVD) in Korean young men and to examine whether serum total cholesterol levels could modify the effect of smoking on ASCVD. DESIGN: A prospective cohort study within a national insurance system. SETTING: Health screenings provided by national insurance in 1992 and 1994. PARTICIPANTS: A total of 118 531 young men between 20 and 29 years of age and were followed up for an average of 23 years. OUTCOME MEASURE: To assess the independent effects of smoking on the risk of ischaemic heart disease (IHD), stroke and ASCVD, Cox proportional hazards regression models were used, controlling for age, hypertension, diabetes, hypercholesterolaemia and alcohol drinking. RESULTS: The total number of current smokers was 78 455 (66.2%), and 94 113 (79.7%) of the sample recorded a total cholesterol level <200 mg/dL measured at baseline. Between 1993 and 2015, 2786 cases of IHD (53/100 000 person year), 2368 cases of stroke (45.4/100 000 person year) and 6368 ASCVD (122.7/100 000 person year) occurred. The risk of IHD, stroke and total ASCVD events was found to increase for current smokers, with a HR with 95% CI of 1.5 (95% CI 1.3 to 1.6), 1.4 (95% CI 1.2 to 1.6) and 1.4 (95% CI 1.3 to 1.5), respectively. Furthermore, the risks above were also found throughout the range of serum levels of cholesterol. CONCLUSIONS: Smoking among Korean young adult men was independently associated with increased risk of IHD, stroke and ASCVD. The concentration of cholesterol in Korean men did not modify the effect of smoking on ASCVD.
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spelling pubmed-65758212019-07-02 Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study Jee, Yongho Jung, Keum Ji Lee, Sunmi Back, Joung Hwan Jee, Sun Ha Cho, Sung-il BMJ Open Epidemiology OBJECTIVE: To examine the effect of smoking on risk of atherosclerotic cardiovascular disease (ASCVD) in Korean young men and to examine whether serum total cholesterol levels could modify the effect of smoking on ASCVD. DESIGN: A prospective cohort study within a national insurance system. SETTING: Health screenings provided by national insurance in 1992 and 1994. PARTICIPANTS: A total of 118 531 young men between 20 and 29 years of age and were followed up for an average of 23 years. OUTCOME MEASURE: To assess the independent effects of smoking on the risk of ischaemic heart disease (IHD), stroke and ASCVD, Cox proportional hazards regression models were used, controlling for age, hypertension, diabetes, hypercholesterolaemia and alcohol drinking. RESULTS: The total number of current smokers was 78 455 (66.2%), and 94 113 (79.7%) of the sample recorded a total cholesterol level <200 mg/dL measured at baseline. Between 1993 and 2015, 2786 cases of IHD (53/100 000 person year), 2368 cases of stroke (45.4/100 000 person year) and 6368 ASCVD (122.7/100 000 person year) occurred. The risk of IHD, stroke and total ASCVD events was found to increase for current smokers, with a HR with 95% CI of 1.5 (95% CI 1.3 to 1.6), 1.4 (95% CI 1.2 to 1.6) and 1.4 (95% CI 1.3 to 1.5), respectively. Furthermore, the risks above were also found throughout the range of serum levels of cholesterol. CONCLUSIONS: Smoking among Korean young adult men was independently associated with increased risk of IHD, stroke and ASCVD. The concentration of cholesterol in Korean men did not modify the effect of smoking on ASCVD. BMJ Publishing Group 2019-06-12 /pmc/articles/PMC6575821/ /pubmed/31196897 http://dx.doi.org/10.1136/bmjopen-2018-024453 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Jee, Yongho
Jung, Keum Ji
Lee, Sunmi
Back, Joung Hwan
Jee, Sun Ha
Cho, Sung-il
Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title_full Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title_fullStr Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title_full_unstemmed Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title_short Smoking and atherosclerotic cardiovascular disease risk in young men: the Korean Life Course Health Study
title_sort smoking and atherosclerotic cardiovascular disease risk in young men: the korean life course health study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575821/
https://www.ncbi.nlm.nih.gov/pubmed/31196897
http://dx.doi.org/10.1136/bmjopen-2018-024453
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