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Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

INTRODUCTION: Self‐ and external‐preoccupation have been linked to psychopathological states. The neural substrates underlying self‐ and external‐preoccupation remain unclear. In the present study, we aim to provide insight into the information‐processing mechanisms associated with self‐ and externa...

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Autores principales: Ikeda, Shigeyuki, Takeuchi, Hikaru, Taki, Yasuyuki, Nouchi, Rui, Yokoyama, Ryoichi, Nakagawa, Seishu, Sekiguchi, Atsushi, Iizuka, Kunio, Hanawa, Sugiko, Araki, Tsuyoshi, Miyauchi, Carlos Makoto, Sakaki, Kohei, Nozawa, Takayuki, Yokota, Susumu, Magistro, Daniele, Kawashima, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576210/
https://www.ncbi.nlm.nih.gov/pubmed/31004413
http://dx.doi.org/10.1002/brb3.1267
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author Ikeda, Shigeyuki
Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Kawashima, Ryuta
author_facet Ikeda, Shigeyuki
Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Kawashima, Ryuta
author_sort Ikeda, Shigeyuki
collection PubMed
description INTRODUCTION: Self‐ and external‐preoccupation have been linked to psychopathological states. The neural substrates underlying self‐ and external‐preoccupation remain unclear. In the present study, we aim to provide insight into the information‐processing mechanisms associated with self‐ and external‐preoccupation at the structural level. METHODS: To investigate the neural substrates of self‐ and external‐preoccupation, we acquired high‐resolution T1‐weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self‐ and external‐preoccupation were estimated using voxel‐based morphometry. RESULTS: Significant positive associations between self‐preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self‐triggered self‐reference during rest. Significant negative associations between external‐preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. CONCLUSION: Our results reveal distinct neural substrates for self‐ and external‐preoccupation at the structural level.
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spelling pubmed-65762102019-06-20 Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study Ikeda, Shigeyuki Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Yokoyama, Ryoichi Nakagawa, Seishu Sekiguchi, Atsushi Iizuka, Kunio Hanawa, Sugiko Araki, Tsuyoshi Miyauchi, Carlos Makoto Sakaki, Kohei Nozawa, Takayuki Yokota, Susumu Magistro, Daniele Kawashima, Ryuta Brain Behav Original Research INTRODUCTION: Self‐ and external‐preoccupation have been linked to psychopathological states. The neural substrates underlying self‐ and external‐preoccupation remain unclear. In the present study, we aim to provide insight into the information‐processing mechanisms associated with self‐ and external‐preoccupation at the structural level. METHODS: To investigate the neural substrates of self‐ and external‐preoccupation, we acquired high‐resolution T1‐weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self‐ and external‐preoccupation were estimated using voxel‐based morphometry. RESULTS: Significant positive associations between self‐preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self‐triggered self‐reference during rest. Significant negative associations between external‐preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. CONCLUSION: Our results reveal distinct neural substrates for self‐ and external‐preoccupation at the structural level. John Wiley and Sons Inc. 2019-04-19 /pmc/articles/PMC6576210/ /pubmed/31004413 http://dx.doi.org/10.1002/brb3.1267 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Ikeda, Shigeyuki
Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Yokota, Susumu
Magistro, Daniele
Kawashima, Ryuta
Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title_full Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title_fullStr Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title_full_unstemmed Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title_short Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study
title_sort neural substrates of self‐ and external‐preoccupation: a voxel‐based morphometry study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576210/
https://www.ncbi.nlm.nih.gov/pubmed/31004413
http://dx.doi.org/10.1002/brb3.1267
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