Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology

Many complex diseases such as cancer are associated with multiple pathological manifestations. Moreover, the therapeutics for their treatments often lead to serious side effects. Thus, it is needed to develop multi-indication therapeutics that can simultaneously target multiple clinical indications...

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Detalles Bibliográficos
Autores principales: Lim, Hansaim, He, Di, Qiu, Yue, Krawczuk, Patrycja, Sun, Xiaoru, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576746/
https://www.ncbi.nlm.nih.gov/pubmed/31206508
http://dx.doi.org/10.1371/journal.pcbi.1006619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576746/
https://www.ncbi.nlm.nih.gov/pubmed/31206508
http://dx.doi.org/10.1371/journal.pcbi.1006619

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