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Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells

Aggrecan is an integral component of the extracellular matrix in cartilaginous tissues, including the growth plate. Heterozygous defects in the aggrecan gene have been identified as a cause of autosomal dominant short stature, bone age acceleration, and premature growth cessation. The mechanisms acc...

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Detalles Bibliográficos
Autores principales: Hodax, Juanita K., Quintos, Jose Bernardo, Gruppuso, Philip A., Chen, Qian, Desai, Salomi, Jayasuriya, Chathuraka T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576788/
https://www.ncbi.nlm.nih.gov/pubmed/31206541
http://dx.doi.org/10.1371/journal.pone.0218399