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Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer’s disease (AD) have largely been developed using these classical laboratory strains, such as C57BL/6J (B6), and this has likely contributed to the failure of t...

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Detalles Bibliográficos
Autores principales:	Onos, Kristen D., Uyar, Asli, Keezer, Kelly J., Jackson, Harriet M., Preuss, Christoph, Acklin, Casey J., O’Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L., Sukoff Rizzo, Stacey J., Soto, Ileana, Carter, Gregory W., Howell, Gareth R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576791/ https://www.ncbi.nlm.nih.gov/pubmed/31150388 http://dx.doi.org/10.1371/journal.pgen.1008155

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