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Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance
Phenotypic plasticity is associated with non-genetic drug tolerance in several cancers. Such plasticity can arise from chromatin remodeling, transcriptomic reprogramming, and/or protein signaling rewiring, and is characterized as a cell state transition in response to molecular or physical perturbat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576794/ https://www.ncbi.nlm.nih.gov/pubmed/31166947 http://dx.doi.org/10.1371/journal.pcbi.1007034 |