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Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

BACKGROUND: Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not...

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Autores principales: Min, Hyang Ki, Sung, Su Ah, Lee, So Young, Lee, Sung Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Nephrology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577221/
https://www.ncbi.nlm.nih.gov/pubmed/30991770
http://dx.doi.org/10.23876/j.krcp.18.0147
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author Min, Hyang Ki
Sung, Su Ah
Lee, So Young
Lee, Sung Woo
author_facet Min, Hyang Ki
Sung, Su Ah
Lee, So Young
Lee, Sung Woo
author_sort Min, Hyang Ki
collection PubMed
description BACKGROUND: Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not been confirmed on a large-scale in the general population. Therefore, we aimed to identify the relationship between hydration status and kidney function. METHODS: We reviewed the data of 28,342 adults who participated in the Korea National Health and Nutrition Examination Surveys. Urine specific gravity unit (SGU) was the primary variable that indicated hydration status, and the estimated glomerular filtration rate (eGFR) was used as the primary outcome. RESULTS: Multivariate linear regression analysis showed urine SGU was positively associated with eGFR, which was J-shaped in the multivariate generalized additive model plot. In the penalized spline curve analysis, the odds ratio for high eGFR was steadily increased. Although increased urine SGU was associated with decreased blood pressure and pulse rate, it had no effect on increased fasting glucose and total cholesterol, suggesting conflicting cardio-metabolic dehydration effects. CONCLUSION: Dehydration, presumably sub-morbid in an ambulatory community-dwelling general population, is associated with higher kidney function. The clinical significance of sub-morbid dehydration-associated glomerular hyperfiltration needs further investigation.
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spelling pubmed-65772212019-06-24 Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality? Min, Hyang Ki Sung, Su Ah Lee, So Young Lee, Sung Woo Kidney Res Clin Pract Original Article BACKGROUND: Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not been confirmed on a large-scale in the general population. Therefore, we aimed to identify the relationship between hydration status and kidney function. METHODS: We reviewed the data of 28,342 adults who participated in the Korea National Health and Nutrition Examination Surveys. Urine specific gravity unit (SGU) was the primary variable that indicated hydration status, and the estimated glomerular filtration rate (eGFR) was used as the primary outcome. RESULTS: Multivariate linear regression analysis showed urine SGU was positively associated with eGFR, which was J-shaped in the multivariate generalized additive model plot. In the penalized spline curve analysis, the odds ratio for high eGFR was steadily increased. Although increased urine SGU was associated with decreased blood pressure and pulse rate, it had no effect on increased fasting glucose and total cholesterol, suggesting conflicting cardio-metabolic dehydration effects. CONCLUSION: Dehydration, presumably sub-morbid in an ambulatory community-dwelling general population, is associated with higher kidney function. The clinical significance of sub-morbid dehydration-associated glomerular hyperfiltration needs further investigation. Korean Society of Nephrology 2019-06 2019-06-30 /pmc/articles/PMC6577221/ /pubmed/30991770 http://dx.doi.org/10.23876/j.krcp.18.0147 Text en Copyright © 2019 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Min, Hyang Ki
Sung, Su Ah
Lee, So Young
Lee, Sung Woo
Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title_full Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title_fullStr Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title_full_unstemmed Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title_short Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
title_sort sub-morbid dehydration-associated glomerular hyperfiltration: an emerging reality?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577221/
https://www.ncbi.nlm.nih.gov/pubmed/30991770
http://dx.doi.org/10.23876/j.krcp.18.0147
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